National Defense University Fundamental Biosciences Department

Target Name: NDUFB7

NCBI ID: G4713

National Defense University Fundamental Biosciences Department

7701 Democracy Boulevard, Washington, DC 20340

Phone: (202) 595-5888

Fax: (202) 595-5888

Email: [info@ndubi@ndu.edu](mailto:info@ndubi@ndu.edu)

Web: [www.ndu.edu](http://www.ndu.edu)

NDUFB7: A Potential Drug Target and Biomarker

NADH-ubiquinone oxidoreductase (NDUFB7) is a subunit of the nuclear respiratory chain (NADH) enzyme, which is involved in the production of NAD+ from NADH. NADH is a crucial co-factor for many cellular processes, including energy metabolism and cellular signaling. The NADH enzyme is a target of many drugs, including statins, which are used to treat hyperlipidemia.

The NDUFB7 subunit has been identified as a potential drug target and biomarker due to its unique structure and its involvement in cellular signaling. TheNDUFB7 subunit is a 17-kDa protein that contains a single catalytic active site and a single prosthetic group. It has been shown to have a highly conserved three-dimensional structure, with a calculated theoretical pI of 8.4, which suggests that it is relatively stable in a variety of cellular environments.

TheNDUFB7 subunit is also known for its role in cellular signaling. It has been shown to be involved in the production of reactive oxygen species (ROS), which can damage cellular components and contribute to cellular stress. Additionally, the NDUFB7 subunit has been shown to be involved in the detoxification of ROS, which may indicate a potential role in protecting against oxidative stress.

TheNDUFB7 subunit has also been shown to be a potential biomarker for certain diseases. For example, studies have shown that the expression of NDUFB7 is increased in the brains of individuals with Alzheimer's disease, which suggests that it may be a potential diagnostic biomarker for this disease . Additionally, the NDUFB7 subunit has been shown to be involved in the production of reactive oxygen species in the liver, which may be a potential biomarker for liver damage.

In conclusion, the NDUFB7 subunit is a unique protein that has been shown to be involved in a variety of cellular processes. Its highly conservative structure and its involvement in cellular signaling and detoxification make it a potential drug target and biomarker. Further research is needed to fully understand the role of the NDUFB7 subunit in cellular signaling and its potential as a drug target.

Protein Name: NADH:ubiquinone Oxidoreductase Subunit B7

Functions: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

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