NEBL: A Potential Drug Target and Biomarker for Actin-Binding Z-Disk Protein

Target Name: NEBL

NCBI ID: G10529

NEBL: A Potential Drug Target and Biomarker for Actin-Binding Z-Disk Protein

The Z-disc protein is a member of the Z-disc family, which is characterized by the presence of a Z-shape in the cytoskeleton of cells. Z-disc proteins are involved in various cellular processes, including cell signaling, cytoskeletal organization, and mechanical forces. One of the Z-disc proteins that has garnered significant interest in recent years is the Actin-binding Z-disk protein (NEBL).

NEBL is a 21-kDa protein that is localized to the centrosome, which is a complex of microtubules that play a crucial role in the organization and movement of cells. The centrosome is composed of several proteins that work together to ensure the proper assembly and disassembly of microtubules. NEBL is one of the proteins that interacts with the microtubules and is involved in the regulation of microtubule dynamics.

Drug Targeting

NEBL has been identified as a potential drug target due to its involvement in the regulation of microtubule dynamics and its role in the development of various diseases, including cancer. Several studies have shown that inhibiting the activity of NEBL can lead to the disruption of microtubule dynamics and the inhibition of cell growth and division.

One of the potential mechanisms by which NEBL can be targeted is by inhibiting the activity of its downstream effectors, such as the myosin ATPase. The myosin ATPase is a protein that is involved in the regulation of muscle contractions and is a key component of the microtubules. By inhibiting the activity of the myosin ATPase, NEBL can prevent the regulation of microtubule dynamics and the proper assembly and disassembly of microtubules.

Another potential mechanism by which NEBL can be targeted is by blocking its interaction with other proteins that interact with it, such as the protein tyrosine phosphatase (PTP). PTP is a protein that is involved in the regulation of protein tyrosine phosphorylation, a process that is essential for the regulation of cellular signaling pathways.

Biomarker

NEBL has also been identified as a potential biomarker for various diseases, including cancer. The disruption of microtubule dynamics, as well as the inhibition of cell growth and division, can be used as biomarkers for various diseases, including cancer.

One of the potential applications of NEBL as a biomarker is its ability to be used as a target for small molecules. Several studies have shown that inhibiting the activity of NEBL with small molecules can lead to the inhibition of microtubule dynamics and the inhibition of cell growth and division. This suggests that NEBL could be a useful biomarker for various diseases, including cancer.

Conclusion

In conclusion, NEBL is a protein that has significant involvement in the regulation of microtubule dynamics and has been identified as a potential drug target and biomarker for various diseases, including cancer. The disruption of microtubule dynamics, as well as the inhibition of cell growth and division, make NEBL an attractive target for small molecules. Further research is needed to fully understand the role of NEBL in cellular signaling pathways and its potential as a drug target and biomarker.

Protein Name: Nebulette

Functions: Binds to actin and plays an important role in the assembly of the Z-disk. May functionally link sarcomeric actin to the desmin intermediate filaments in the heart muscle sarcomeres (PubMed:27733623). Isoform 2 might play a role in the assembly of focal adhesion (PubMed:15004028)

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