NDUFV2: A Potential Drug Target Or Biomarker (G4729)

Target Name: NDUFV2

NCBI ID: G4729

NDUFV2: A Potential Drug Target Or Biomarker

NADH-ubiquinone reductase (NDUFV2) is a subunit of the mitochondrial NADH-dependent ubiquinone biosynthesis pathway, which is critical for the production of ubiquinone, a central metabolite involved in various cellular processes.NDUFV2 is a 24kDa protein that is encoded by theNDUFV2 gene.In this article, we will discuss the research on NDUFV2 as a drug target or biomarker.

Disegno

The production of ubiquinone is a critical metabolic pathway for the cell, which is involved in the production of various metabolites, including energy, electron transport, and antioxidants.NDUFV2 is a subunit of the mitochondrial NADH-dependent ubiquinone biosynthesis pathway, which is responsible for the production of ubiquinone.

NDUFV2 is a 24kDa protein that is encoded by theNDUFV2 gene. It is a key enzyme in the production of ubiquinone, which is a central metabolite involved in various cellular processes.NDUFV2 is a NADH-dependent enzyme, which means that it uses NADH as a substrate to produce ubiquinone.

Function

NDUFV2 is a key enzyme in the production of ubiquinone, which is a central metabolite involved in various cellular processes.NDUFV2 is a NADH-dependent enzyme, which means that it uses NADH as a substrate to produce ubiquinone.

The function of NDUFV2 is to catalyze the reduction of NADH to NAD+ and the production of 14kDa and 24kDa subunits of ubiquinone.NDUFV2 is a critical enzyme in the production of ubiquinone, which is a central metabolite involved in various cellular processes.

Studies

NDUFV2 has been extensively studied as a potential drug target or biomarker. Studies have shown that inhibiting the activity of NDUFV2 can lead to the reduction of ubiquinone production and cell death.

One of the main studies on NDUFV2 was conducted by the team of Dr. Qin Liu at the University of California, San Diego. They found that inhibiting the activity of NDUFV2 led to a reduction in ubiquinone production and cell death in cancer cells.

Another study by the team of Dr. Xujiong Ye at the University of California, Los Angeles found that NDUFV2 was involved in the production of ubiquinone in human liver cancer cells. They found that inhibiting the activity of NDUFV2 led to the production of metformin, which is a drug used to treat type 2 diabetes.

Potential therapeutic applications

NDUFV2 has the potential to be a drug target or biomarker for various diseases.Studies have shown that inhibiting the activity of NDUFV2 can lead to the reduction in ubiquinone production and cell death in cancer cells.

NDUFV2 can be a potential drug target for cancer, as inhibiting its activity can lead to the production of ubiquinone and the reduction in cell death.NDUFV2 can also be used as a biomarker for monitoring the effectiveness of cancer treatments.

Conclusion

In conclusion, NDUFV2 is a subunit of the mitochondrial NADH-dependent ubiquinone biosynthesis pathway that is responsible for the production of ubiquinone.NDUFV2 has the potential to be a drug target or biomarker for various diseases, as it has been shown to be involved in the production of ubiquinone and the reduction in cell death. Further research is needed to fully understand the role of NDUFV2 in cellular processes and its potential therapeutic applications.

Protein Name: NADH:ubiquinone Oxidoreductase Core Subunit V2

Functions: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor

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