NDUFB3: A Potential Drug Target and Biomarker (G4709)

Target Name: NDUFB3

NCBI ID: G4709

NDUFB3: A Potential Drug Target and Biomarker

NADH:ubiquinone oxidoreductase (NDUFB3) is a subunit of the cytochrome P450 enzyme family, which is responsible for metabolizing a wide variety of drugs, including many statins, thiopurine drugs, and benzodiazepines. Mutations in the NDUFB3 gene have been linked to reduced efficacy and increased side effects of these drugs, which has led to a growing interest in developing drugs that target this enzyme.

In addition to its role in drug metabolism, NDUFB3 is also a potential drug target itself. The NDUFB3 enzyme has been shown to play a key role in the regulation of cellular processes that are important for the development and maintenance of cancer. Specifically, NDUFB3 has has been shown to be involved in the production of reactive oxygen species (ROS), which can contribute to the development of oxidative stress and contribute to the development of cancer.

The ability of NDUFB3 to generate ROS has led to the hypothesis that targeting this enzyme may be an effective way to prevent or treat cancer. Several studies have shown that inhibiting the activity of NDUFB3 can reduce the production of ROS and inhibit the growth of cancer cells . In addition, several studies have also shown that inhibiting the activity of NDUFB3 can increase the sensitivity of cancer cells to chemotherapy.

In addition to its potential as a drug target, NDUFB3 has also been shown to be a potential biomarker for cancer. The production of ROS by NDUFB3 is well established, and several studies have shown that the levels of ROS are significantly elevated in the blood and urine of cancer patients compared to healthy individuals. In addition, the levels of ROS have also been shown to be elevated in the breast tissue of women with breast cancer.

These findings suggest that NDUFB3 may be an attractive target for cancer treatment, particularly in cases where the production of ROS is increased. Further research is needed to fully understand the role of NDUFB3 in the development and progression of cancer, as well as the most effective ways to target this enzyme.

In conclusion, NDUFB3 is a subunit of the cytochrome P450 enzyme family that is involved in the regulation of cellular processes that are important for the development and maintenance of cancer. The production of ROS by NDUFB3 has led to the hypothesis that targeting this enzyme may be an effective way to prevent or treat cancer. In addition to its potential as a drug target, NDUFB3 has also been shown to be a potential biomarker for cancer. Further research is needed to fully understand the role of NDUFB3 in the development and progression of cancer. , as well as the most effective ways to target this enzyme.

Protein Name: NADH:ubiquinone Oxidoreductase Subunit B3

Functions: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

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