NDRG3: A Potential Drug Target for Neural Development, Plasticity, Pain Perception and Cancer

Target Name: NDRG3

NCBI ID: G57446

NDRG3: A Potential Drug Target for Neural Development, Plasticity, Pain Perception and Cancer

NDRG3 (NDRG3_HUMAN) is a protein that is expressed in various tissues of the human body. It is a member of the neurotrophic factor receptor family and is involved in the regulation of neural development, plasticity, and survival. NDRG3 has been identified as a potential drug target and has been shown to play a role in several neurological and psychiatric disorders.

The NDRG3 protein is composed of 154 amino acid residues and has a molecular weight of 19.1 kDa. It is expressed in a variety of tissues, including the brain, spinal cord, pancreas, and heart. NDRG3 is highly conserved across different species, with only minor differences in its sequence.

NDRG3 is involved in the development and maintenance of neural stem cells and neural stem cell progeny. It has been shown to promote the self-renewal and proliferation of neural stem cells and to play a role in the development of neural plasticity. NDRG3 has also been shown to regulate the differentiation of neural stem cells into functional neurons, which may have implications for the treatment of neurological and psychiatric disorders.

In addition to its role in neural development and plasticity, NDRG3 is also involved in the regulation of pain perception and neuroinflammation. It has been shown to play a role in the development of pain-related disorders and to contribute to neuroinflammation. This suggests that NDRG3 may be a useful target for the treatment of pain and neuroinflammation-related disorders.

NDRG3 has also been shown to be involved in the regulation of cell survival and has been implicated in the development of cancer. It has been shown to be involved in the regulation of cell apoptosis, which is the process by which cells die as a result of environmental stressors or genetic changes. NDRG3 has also been shown to contribute to the development of cancer by promoting the survival of cancer cells and by inhibiting the apoptosis of normal cells. This suggests that NDRG3 may be a useful target for the development of cancer therapies.

In conclusion, NDRG3 is a protein that is involved in a variety of physiological processes in the human body. It is potential drug target and has been shown to play a role in the development and regulation of neural development, plasticity, pain perception, neuroinflammation, and cancer. Further research is needed to fully understand the role of NDRG3 in these processes and to develop effective treatments for the underlying disorders.

Protein Name: NDRG Family Member 3

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