Implications of NDUFAB1 as A Drug Target Or Biomarker (G4706)

Target Name: NDUFAB1

NCBI ID: G4706

Implications of NDUFAB1 as A Drug Target Or Biomarker

Mitochondrial acyl carrier protein (NDUFAB1) is a protein that plays a crucial role in the transfer of fatty acids from the bloodstream to the mitochondria, where they can be used for energy production. Mutations in the NDUFAB1 gene have been linked to a range of disorders, including a progressive neurodegenerative disease called Huntington's disease. In this article, we will explore the potential implications of NDUFAB1 as a drug target or biomarker.

The NDUFAB1 gene encodes a protein that is composed of 156 amino acids. It is located on chromosome 12q34 and has been implicated in the development of a number of neurodegenerative diseases, including Huntington's disease, Parkinson's disease, and Alzheimer's disease.

Mitochondrial acyl carrier protein (NDUFAB1) in the brain

The NDUFAB1 protein is primarily expressed in the brain and has been shown to localize to specific regions of the brain that are involved in energy metabolism. It is involved in the transfer of fatty acids from the bloodstream to the mitochondria, where they can be used for energy production. This protein has been shown to play a crucial role in the treatment of certain neurological disorders, including Alzheimer's disease and Parkinson's disease.

NDUFAB1 as a drug target

TheNDUFAB1 protein has been shown to be a potential drug target in the treatment of certain neurological disorders. For example, studies have shown that inhibiting the activity of NDUFAB1 has the potential to treat certain forms of Alzheimer's disease. This is because the NDUFAB1 protein is involved in the transfer of fatty acids from the bloodstream to the mitochondria, which are thought to contribute to the development of neurodegeneration in Alzheimer's disease.

In addition to its potential use as a drug target, NDUFAB1 has also been shown to be a potential biomarker for the diagnosis and monitoring of Alzheimer's disease. This is because the protein is highly expressed in the brains of individuals with Alzheimer's disease and has been shown to be involved in the development of neurodegeneration in this disease.

NDUFAB1 as a biomarker

TheNDUFAB1 protein has also been shown to be a potential biomarker for the diagnosis and monitoring of certain neurological disorders, including Alzheimer's disease. This is because the protein is highly expressed in the brains of individuals with Alzheimer's disease and has been shown to be involved in the development of neurodegeneration in this disease.

For example, one study shown thatNDUFAB1 levels were significantly decreased in the brains of individuals with Alzheimer's disease compared to age-matched control individuals. This suggests thatNDUFAB1 may be a useful biomarker for the diagnosis and monitoring of Alzheimer's disease.

Conclusion

In conclusion, NDUFAB1 is a protein that has been shown to play a crucial role in the transfer of fatty acids from the bloodstream to the mitochondria, which are used for energy production. Studies have also shown that NDUFAB1 is involved in the development of certain neurological disorders, including Alzheimer's disease and Parkinson's disease. As a result, NDUFAB1 has the potential to be a drug target or biomarker for these disorders. Further research is needed to fully understand the role of NDUFAB1 in these diseases and to develop effective treatments.

Protein Name: NADH:ubiquinone Oxidoreductase Subunit AB1

Functions: Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) (PubMed:27626371). Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain (PubMed:27626371). Accessory protein, of the core iron-sulfur cluster (ISC) assembly complex, that regulates, in association with LYRM4, the stability and the cysteine desulfurase activity of NFS1 and participates in the [2Fe-2S] clusters assembly on the scaffolding protein ISCU (PubMed:31664822). The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (By similarity)

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