Regulation of Nuclear Import and Export By NDEL1: Potential Drug Targets Or Biomarkers

Target Name: NDEL1

NCBI ID: G81565

Regulation of Nuclear Import and Export By NDEL1: Potential Drug Targets Or Biomarkers

Nuclear distribution protein nudE-like 1 (NDEL1) is a protein that is expressed in various tissues and organs in the human body. It is a member of the nucleoprotein family and is responsible for the delivery of various proteins to the nuclear envelope. NDEL1 has been shown to play a crucial role in the regulation of nuclear import and export, and is thus a potential drug target or biomarker.

The nuclear envelope is a double membrane structure that surrounds the nucleus of the cell and serves as the barrier between the cytoplasm and the nucleus. It is made up of various proteins that help to regulate the import and export of molecules into the nucleus. NDEL1 is one of these proteins, and is responsible for the delivery of proteins such as activator protein 1 (AP-1) and hsp70 to the nuclear envelope.

NDEL1 is a 21-kDa protein that is expressed in various tissues and organs, including muscle, heart, liver, and brain. It is primarily localized to the endoplasmic reticulum (ER) and nuclear envelope, and is involved in the delivery of a wide variety of proteins to the nuclear envelope. In addition to its role in protein delivery, NDEL1 has also been shown to play a role in the regulation of nuclear import and export.

NudE-like 1 (NDEL1) has been shown to regulate the import of various proteins into the nucleus. For example, studies have shown that NDEL1 can prevent the import of the transcriptional factor p53 into the nucleus, and can also inhibit the import of the oncogene c-Fas. This suggests that NDEL1 may play a role in the regulation of nuclear stress responses and the regulation of gene expression.

In addition to its role in protein delivery and import, NDEL1 has also been shown to regulate the export of proteins from the nucleus. Studies have shown that NDEL1 can prevent the export of the transcription factor p21, and can also inhibit the export of the oncogene src. This suggests that NDEL1 may play a role in the regulation of nuclear stress responses and the regulation of gene expression.

The potential drug target or biomarker properties of NDEL1 are due to its role in the regulation of nuclear import and export. Studies have shown that inhibiting the activity of NDEL1 can lead to increased levels of various proteins in the nucleus, such as activator protein 1 (AP-1), hsp70, and src. This suggests thatNDEL1 may be a useful drug target or biomarker for various diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases.

In conclusion, NDEL1 is a protein that is expressed in various tissues and organs and is involved in the delivery of proteins to the nuclear envelope. It has been shown to play a crucial role in the regulation of nuclear import and export and is thus a potential drug target or biomarker for various diseases. Further research is needed to fully understand the role of NDEL1 in the regulation of nuclear import and export and to develop effective treatments for diseases associated with these processes.

Protein Name: NudE Neurodevelopment Protein 1 Like 1

Functions: Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity)

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