NDE1: A Drug Target / Disease Biomarker (G54820)

Target Name: NDE1

NCBI ID: G54820

NDE1: A Drug Target / Disease Biomarker

NDE1, or N-acyl-L-histidine, is a protein that is expressed in various tissues throughout the body. It is a key player in the regulation of cell signaling pathways, particularly in the signaling pathway known as the TGF-β pathway. This pathway is involved in the development, maintenance, and regulation of tissues, and is a prime target for many diseases. As a result, NDE1 has been identified as a potential drug target and a biomarker for a variety of diseases.

The TGF-β pathway is a critical signaling pathway that is involved in the regulation of cellular processes such as cell growth, differentiation, and inflammation. This pathway is composed of several transcription factors, including TGF-β1, TGF-β2, and BMP-1. TGF-β1 and BMP-1 are involved in the regulation of cell proliferation, while TGF-β2 is involved in the regulation of cell differentiation. The activity of these transcription factors is regulated by the NDE1 protein.

NDE1 is a key player in the regulation of TGF-β pathway activity. It is a protein that can bind to the N-terminus of TGF-β1 and TGF-β2, and can also interact with the C-terminus of BMP-1. This interaction between NDE1 and TGF-β transcription factors allows NDE1 to regulate the activity of these transcription factors.

In addition to its role in the TGF-β pathway, NDE1 is also involved in the regulation of cell signaling pathways that are not related to the TGF-β pathway. For example, NDE1 has been shown to be involved in the regulation of the Wnt signaling pathway, which is involved in the development and maintenance of tissues.

As a result of its involvement in these various signaling pathways, NDE1 has been identified as a potential drug target and biomarker for a variety of diseases. For example, NDE1 has been shown to be involved in the development of cancer, and has been identified as a potential therapeutic target for this disease. In addition, NDE1 has also been shown to be involved in the regulation of autoimmune diseases, such as rheumatoid arthritis and lupus.

In addition to its potential therapeutic applications, NDE1 is also an attractive biomarker for the diagnosis of these diseases. The regulation of TGF-β pathway activity by NDE1 is often altered in diseases such as cancer, autoimmune diseases, and neurodegenerative diseases. This alteration can be detected using techniques such as qRT-PCR, a technique that allows researchers to detect and measure the levels of specific genes in a sample.

Overall, NDE1 is a protein that is involved in the regulation of various signaling pathways and has been identified as a potential drug target and biomarker for a variety of diseases. Further research is needed to fully understand the role of NDE1 in these processes and to develop effective therapies for these diseases.

Protein Name: NudE Neurodevelopment Protein 1

Functions: Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a post-mitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex

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