Target Name: MCOLN2
NCBI ID: G255231
Other Name(s): Mucolipin TRP cation channel 2, transcript variant 1 | Mucolipin-2 (isoform 1) | Mucolipin-2 | Transient receptor potential channel mucolipin 2 | FLJ36691 | Mucolipin 2 | transient receptor potential channel mucolipin 2 | TRP-ML2 | TRPML2 | mucolipin TRP cation channel 2 | mucolipin 2 | MCLN2_HUMAN | MCOLN2 variant 1

MCOLN2: A Protein Regulating Cation Channels and Cell Signaling Pathways

Mucolipin TRP cation channel 2 (MCOLN2), also known as transcript variant 1, is a protein that plays a crucial role in various physiological processes in the body. It is a member of the TRP cation channel family, which are known for their ability to regulate ion channels in various tissues, including the epithelial membrane and the basal membrane of various body organs.

MCOLN2 is a 21-kDa protein that is expressed in various tissues and organs, including the skin, hair, nails, and heart. It is highly expressed in the epithelial tissue, which is responsible for the formation of various body surfaces and organs. This is because of its function in cell-cell adhesion and the regulation of cell signaling pathways that are critical for tissue development and maintenance.

One of the unique features of MCOLN2 is its ability to form a cation channel that allows it to regulate the movement of positively charged ions, such as calcium and magnesium ions, in and out of cells. This channel plays a crucial role in the regulation of Various physiological processes, including muscle contractions, nerve impulses, and the regulation of blood pressure.

MCOLN2 is also known for its role in the regulation of cell signaling pathways that are critical for tissue development and maintenance. It is a key regulator of the Wnt signaling pathway, which is involved in the regulation of cell proliferation and the formation of various tissues in the body.

In addition to its role in cell signaling pathways, MCOLN2 is also known for its role in the regulation of ion channels in various tissues. It is a regulator of the K+, Na+, and Ca2+ channels in the epithelial membrane, which are responsible for the Regulation of various physiological processes, including cell signaling pathways and the regulation of ion transport.

MCOLN2 is also expressed in other tissues and organs, including the heart, where it is involved in the regulation of cardiac muscle contractions. It is also expressed in the nervous system, where it plays a role in the regulation of neural signaling pathways.

Given its unique function in the regulation of various physiological processes, MCOLN2 has potential as a drug target or biomarker. Researchers are currently studying the use of small molecules and other compounds to modulate the activity of MCOLN2 and its role in various physiological processes.

In conclusion, Mucolipin TRP cation channel 2 (MCOLN2) is a protein that plays a crucial role in various physiological processes in the body. Its unique ability to form a cation channel and its regulation of cell signaling pathways make it an attractive target for research and development as a drug or biomarker. Further research is needed to fully understand the role of MCOLN2 in various tissues and organs, and to develop effective strategies for the modulation of its activity.

Protein Name: Mucolipin TRP Cation Channel 2

Functions: Nonselective cation channel probably playing a role in the regulation of membrane trafficking events. Acts as Ca(2+)-permeable cation channel with inwardly rectifying activity (PubMed:19940139, PubMed:19885840). May activate ARF6 and be involved in the trafficking of GPI-anchored cargo proteins to the cell surface via the ARF6-regulated recycling pathway (PubMed:17662026). May play a role in immune processes. In adaptive immunity, TRPML2 and TRPML1 may play redundant roles in the function of the specialized lysosomes of B cells (By similarity). In the innate immune response, may play a role in the regulation of chemokine secretion and macrophage migration (By similarity). Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events (PubMed:19885840)

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MCOLN3 | MCPH1 | MCPH1-AS1 | MCPH1-DT | MCRIP1 | MCRIP2 | MCRS1 | MCTP1 | MCTP2 | MCTS1 | MCTS2 | MCU | MCUB | MCUR1 | MDC1 | MDFI | MDFIC | MDGA1 | MDGA2 | MDH1 | MDH1B | MDH2 | MDK | MDM1 | MDM2 | MDM4 | MDN1 | MDS2 | ME1 | ME2 | ME3 | MEA1 | MEAF6 | MEAF6P1 | MEAK7 | Mechanoelectrical transducer (MET) channel | Mechanosensitive Ion Channel | MECOM | MECOM-AS1 | MeCP1 histone deacetylase (HDAC) complex | MECP2 | MECR | MED1 | MED10 | MED11 | MED12 | MED12L | MED13 | MED13L | MED14 | MED14P1 | MED15 | MED15P8 | MED16 | MED17 | MED18 | MED19 | MED20 | MED21 | MED22 | MED23 | MED24 | MED25 | MED26 | MED27 | MED28 | MED29 | MED30 | MED31 | MED4 | MED4-AS1 | MED6 | MED7 | MED8 | MED9 | MEDAG | Mediator Complex | Mediator of RNA Polymerase II Transcription | MEF2A | MEF2B | MEF2C | MEF2C-AS1 | MEF2C-AS2 | MEF2D | MEFV | MEG3 | MEG8 | MEG9 | MEGF10 | MEGF11 | MEGF6 | MEGF8 | MEGF9 | MEI1 | MEI4 | MEIG1 | MEIKIN | MEIOB | MEIOC | MEIOSIN