SNORD12C: A Potential Drug Target and Biomarker for Small Nucleolar Organelles

Target Name: SNORD12C

NCBI ID: G26765

Other Name(s): RNA, U106 small nucleolar | E3 | RNU106 | small nucleolar RNA, C/D box 12C | Small nucleolar RNA, C/D box 106 | SNORD106 | E2-1 | Small nucleolar RNA, C/D box 12C | E2 | U106

SNORD12C: A Potential Drug Target and Biomarker for Small Nucleolar Organelles

Small nucleolar organelles (SNORDs) are a type of RNA molecule that play a critical role in the regulation of gene expression and cell growth. SNORDs are composed of a core RNA molecule and a variety of different subunits that can modulate the stability and localization of the core RNA. Despite the importance of SNORDs in cellular processes, many SNORDs have not been identified or characterized. However, one potential drug target and biomarker for SNORDs is SNORD12C.

SNORD12C is a small nucleolar RNA (snRNA) that is expressed in most tissues and cells. It is characterized by a unique 12-nt primary structure and a conserved secondary structure that includes a single-stranded region, a 2'-overhang, and a terminal 3'-end. SNORD12C is expressed in high abundance in the nuclei of actively dividing cells and is involved in the regulation of gene expression and cell growth.

One of the unique features of SNORD12C is its ability to interact with other SNORDs. This interaction occurs through a process called homomeric interaction, which involves the formation of a double-stranded RNA structure by the complementary base pairs between the SNORDs. Homomeric interaction is a process that is highly regulated in SNORDs, and it is thought to play a role in the regulation of gene expression and cell growth.

SNORD12C has also been shown to interact with the protein Snail, which is a key regulator of the cell nucleus. The interaction between SNORD12C and Snail allows for the regulation of gene expression and the control of cell growth. This interaction between SNORD12C and Snail also suggests that they may be potential drug targets.

In addition to its potential as a drug target, SNORD12C may also be a useful biomarker for the diagnosis and treatment of various diseases. The regulation of gene expression is a critical aspect of many diseases, including cancer, neurodegenerative diseases, and developmental disorders. Therefore, the regulation of SNORD12C expression levels may be a useful biomarker for the diagnosis and treatment of these diseases.

SNORD12C has also been shown to be involved in the regulation of cellular processes that are important for the development and maintenance of cancer. For example, studies have shown that SNORD12C is involved in the regulation of the cell cycle, which is a critical aspect of cancer development. Additionally, SNORD12C has been shown to be involved in the regulation of cell apoptosis, which is a critical aspect of cancer treatment.

In conclusion, SNORD12C is a small nucleolar RNA that is expressed in most tissues and cells and is involved in the regulation of gene expression and cell growth. Its unique 12-nt primary structure and conserved secondary structure make it a potential drug target and biomarker for SNORDs. The interaction between SNORD12C and the protein Snail also suggests that they may be potential drug targets for the regulation of gene expression and cell growth. Additionally, SNORD12C has been shown to be involved in the regulation of cellular processes that are important for the development and maintenance of cancer, making it a potential biomarker for the diagnosis and treatment of these diseases. Further research is needed to fully understand the role of SNORD12C in cellular processes and its potential as a drug target and biomarker.

Protein Name: Small Nucleolar RNA, C/D Box 12C

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