SNORD14D: A Potential Drug Target and Biomarker (G85390)

Target Name: SNORD14D

NCBI ID: G85390

Other Name(s): small nucleolar RNA, C/D box 14D | Small nucleolar RNA, C/D box 14D

SNORD14D: A Potential Drug Target and Biomarker

Small nucleolar RNA (snRNA) is a class of non-coding RNA molecules that plays a critical role in the regulation of gene expression in eukaryotic cells. One of the most well-known snRNAs is SNORD14D, which is located within the C/D box 14D region of the human snRNA molecule.

The C/D box 14D region of snRNA is a highly conserved region that is involved in various cellular processes, including DNA replication, transcription, and translation of RNA. The region contains several putative binding sites that are known to interact with various protein factors, including transcription factors. Therefore, the study of SNORD14D and its potential functions as a drug target or biomarker is of great interest.

SNORD14D is a 24.1 kilobase (kb) long RNA molecule that contains 19 exons and 16 introns. The molecule has a highly conserved structure, with a closed double helix that consists of two main arms: one arm contains a 5'-end and the other arm contains a 3'-end. The 5'-end region of SNORD14D contains a conserved core that is known as the P1A domain, which is a common structural motif that is present in various snRNAs.

The 3'-end region of SNORD14D contains a unique feature that is not found in other snRNAs, known as the D14 region. The D14 region is a 7.8 kb long sequence that contains a specific strongly conserved elements that is involved in the formation of a stem-loop structure. The stem-loop structure is a common motif that is found in various snRNAs and is composed of a series of alternating G/C and A/T base pairs that form a closed loop.

The conserved core of SNORD14D, including the P1A domain and the D14 region, has been studied extensively to determine its functions in various cellular processes. One of the most well-known functions of SNORD14D is its role in the regulation of gene expression. The P1A domain is known to interact with various transcription factors, including the RNA polymerase II (RNA-P2) complex, which is responsible for transcription of DNA templates. Therefore, SNORD14D is a potential drug target that can be targeted by small molecule inhibitors to disrupt the function of RNA-P2 and potentially inhibit gene expression.

In addition to its role in gene expression, SNORD14D is also a potential biomarker for various diseases, including cancer. The D14 region of SNORD14D has been shown to be overexpressed in various cancer tissues, including breast, ovarian, and colorectal cancer. Therefore, the study of SNORD14D as a potential biomarker for cancer has significant implications for the development of new diagnostic tests and therapies.

The structure and function of SNORD14D have also been studied in the context of its potential role as a drug target. Many small molecules have been shown to interact with the conserved core of SNORD14D, including inhibitors of RNA-P2, which may disrupt the function of the molecule and lead to the inhibition of gene expression. Therefore, the study of SNORD14D as a potential drug target is an area of 鈥嬧?媜ngoing research that may lead to the development of new therapeutic agents for various diseases.

In conclusion, SNORD14D is a well-studied snRNA molecule that has significant implications for the regulation of gene expression and the development of new therapeutic agents for various diseases. The conserved core of the molecule, including the P1A domain and the D14 region, has been shown to interact with various transcription factors, making it a potential drug target. The study of SNORD14D as a potential biomarker for cancer and its role as a drug target is an area of 鈥嬧?媜ngoing research that may lead to the development of new diagnostic tests and therapies

Protein Name: Small Nucleolar RNA, C/D Box 14D

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