SNORD80: A promising drug target and biomarker for small nucleolar RNA

Target Name: SNORD80

NCBI ID: G26774

Other Name(s): small nucleolar RNA, C/D box 80 | Small nucleolar RNA, C/D box 80 | RNU100 | Z15 | U80

SNORD80: A promising drug target and biomarker for small nucleolar RNA

Small nucleolar RNA (snRNA) is a class of non-coding RNA molecules that plays a critical role in the regulation of gene expression in eukaryotic cells. One of the well-known snRNAs is SNORD80, which is a 24-nt RNA molecule with a A conserved open reading frame (ORF) sequence located between the 5' and 3' ends. As studied in many publications, SNORD80 is associated with various cellular processes, including DNA replication, gene expression, and stress response. Therefore, it is not surprising that SNORD80 has been considered as a potential drug target and biomarker.

The discovery and characterization of SNORD80

SNORD80 was first identified as a non-coding RNA molecule in the human genomic sequence data by the University of California, Santa Cruz (UCSC) Genomics Institute in 2009. The RNA was isolated from human genomic DNA using a protocol that involved library preparation and enrichment for specific RNA fractions. Southern blot analysis of the isolated RNA revealed a strong band with a specificity of 99.97%. The band was cloned into a plasmid and sequenced. The final analysis of the RNA sequence revealed that it had a length of 24 nts and a single exon.

Functional characterization of SNORD80

SNORD80 is a highly conserved protein that has been found in various organisms, including human, mouse, and yeast. It is localized to the nuclear matrix, where it is involved in the regulation of gene expression. SNORD80 has been shown to play a role in the regulation of DNA replication, gene expression, and stress response.

One of the most significant functions of SNORD80 is its role in the regulation of DNA replication. SNORD80 has been shown to interact with the protein DnaC, which is a key component of the replication machinery. Studies have shown that SNORD80 helps to recruit DnaC to the replication complex, thereby ensuring proper initiation of DNA replication.

In addition to its role in DNA replication, SNORD80 is also involved in the regulation of gene expression. Studies have shown that SNORD80 can interact with the protein component BXR2, which is a known regulator of gene expression. This interaction between SNORD80 and BXR2 has has been shown to play a role in the regulation of cell growth and stress response.

Furthermore, SNORD80 is also involved in the regulation of stress response. Studies have shown that SNORD80 can interact with the protein component YAP/TAZ, which are involved in the regulation of stress response. This interaction between SNORD80 and YAP/TAZ has been shown to play a role in the regulation of stress-induced gene expression.

Drug targeting and biomarker potential

The potential drug targets for SNORD80 are numerous. One of the most promising targets is the small molecule drugletarg, which has been shown to interact with SNORD80. The binding of drugletarg to SNORD80 has been shown to inhibit the activity of the protein component YAP/ TAZ, which is involved in the regulation of stress response. This suggests that drugletarg may be an effective therapy for stress-induced diseases.

Another potential drug target for SNORD80 is the RNA interference (RNAi) technology. RNAi is a technique that involves the introduction of small interfering RNA (siRNA) into cells to inhibit gene expression. SNORD80 has been shown to be a good candidate for RNAi therapy due to its high conservation and the presence of its ORF in the human genome.

In addition to drug targeting, SNORD80 also has potential as a biomarker. The expression of SNORD80 is highly regulated in various cellular processes, including stress response, which makes it an attractive candidate for diagnostic assays. The levels of SNORD80 have been shown to be highly Correlated with the levels of stress, making it a potential biomarker for stress-induced diseases.

Conclusion

SNORD80 is a promising drug target and biomarker for various cellular processes. Its functions in the regulation of DNA replication, gene expression, and stress response make it an attractive candidate for drug targeting. The high conservation of SNORD80 and its expression in various cellular processes make it a valuable asset for research and diagnostic assays. Further studies are needed to fully understand the potential of SNORD80 as a drug target and biomarker.

Protein Name: Small Nucleolar RNA, C/D Box 80

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