SNORD84: A Potential Drug Target and Biomarker for Small Nucleolar RNA

Target Name: SNORD84

NCBI ID: G692199

Other Name(s): small nucleolar RNA, C/D box 84 | Small nucleolar RNA, C/D box 84 | U84

SNORD84: A Potential Drug Target and Biomarker for Small Nucleolar RNA

Small nucleolar RNA (snRNA) is a non-coding RNA molecule that plays a critical role in the regulation of gene expression in eukaryotic cells. One of the most well-known snRNAs is SNORD84, which is a 22-nt RNA molecule that is expressed in various cell types and is involved in the regulation of microRNA (miRNA) translation. SNORD84 has been identified as a potential drug target and biomarker due to its unique structure and function.

Structure and Function

SNORD84 is a small RNA molecule that contains a characteristic C/D box, which is a common structural feature of snRNAs. The C/D box is composed of a conserved core region and a variable extension region that includes a loop and a stem. The C/D box is responsible for binding to various protein factors, which in turn regulate the translation of snRNAs.

SNORD84 is a highly conserved protein that has been identified in various cell types, including bacteria, yeast, and plants. It is expressed in the nuclei of eukaryotic cells and is involved in the regulation of gene expression. One of the most interesting aspects of SNORD84 is its ability to interact with specific protein factors to regulate the translation of snRNAs.

Recent studies have demonstrated that SNORD84 can interact with several protein factors, including the translation factor TF-1, which is responsible for translating the miRNA precursors from the endoplasmic reticulum to the cytoplasm. TF-1 recognizes the Phe-rich region of the C/D box of SNORD84 and binds to it, which in turn regulates the translation of miRNA precursors.

SNORD84 is also known to interact with the protein Skr5, which is involved in the regulation of gene expression in various cell types. Skr5 recognizes the GppG repeats in the C/D box of SNORD84 and binds to it, which in turn regulates the translation of snRNAs.

Drug Target Potential

SNORD84 has been identified as a potential drug target due to its unique structure and function. The C/D box of SNORD84 makes it a potential target for small molecule inhibitors, which can be used to regulate the activity of SNORD84. Additionally, the fact that SNORD84 is involved in the regulation of gene expression makes it an attractive target for drugs that aim to modify gene expression levels.

Biomarker Potential

SNORD84 has also been identified as a potential biomarker for various diseases, including cancer. The regulation of gene expression by SNORD84 is disrupted in various cancer types, which makes it an attractive target for cancer therapies. Additionally, the conserved nature of SNORD84 across different organisms makes it a potential biomarker for various diseases.

Conclusion

SNORD84 is a unique small RNA molecule that plays a critical role in the regulation of gene expression in eukaryotic cells. Its structure and function make it an attractive target for small molecule inhibitors and biomarkers. Further research is needed to fully understand the role of SNORD84 in various cell types and to develop effective therapies based on its unique properties.

Protein Name: Small Nucleolar RNA, C/D Box 84

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