SOAT1: Encoding A Protein Involved in ER-mediated Sterol Transport and Procession

Target Name: SOAT1

NCBI ID: G6646

SOAT1: Encoding A Protein Involved in ER-mediated Sterol Transport and Procession

SOAT1 (Sterol O-acyltransferase 1) is a gene that encodes a protein located in the endoplasmic reticulum (ER) of the cell. The ER is a membrane system, which is a system of membrane-bound organelles that functions as a quality control and sorting center for the cell. It is responsible for the transport and processing of various molecules, including drugs and other substances that are brought into the cell by the bloodstream or by other means.

SOAT1 is a member of the sterol transferase family, which is a group of enzymes that are involved in the transfer of sterols, such as cholesterol and other fatty acids, from the cytoplasm to the ER. These enzymes work by transferring the sterol to a transmembrane protein, which in turn is processed and then released into the ER.

SOAT1 is expressed in most tissues of the body and is involved in the transport of sterols from the cytoplasm to the ER. It is also involved in the processing of these sterols and in the production of other molecules that are used by the cell.

Some studies have suggested that SOAT1 may be a drug target or biomarker for a variety of diseases. For example, SOAT1 has been shown to be involved in the transport of certain drugs, such as statins, which are used to treat conditions such as heart disease and diabetes. It has also been shown to be involved in the production of certain signaling molecules, such as the sterol regulatory protein (SRP), which is involved in the production of cholesterol.

In addition to its role in drug transport and signaling, SOAT1 is also involved in the regulation of cellular processes that are important for the survival and function of the cell. For example, SOAT1 has been shown to be involved in the production of the molecule hydrophobic Fatty acid (hydrophobic fatty acid), which is important for the structure and function of cell membranes. It is also involved in the production of other molecules that are involved in the regulation of cellular processes, such as the production of energy.

In conclusion, SOAT1 is a gene that encodes a protein that is involved in the transport and processing of sterols in the ER of the cell. It is expressed in most tissues of the body and is also involved in the production of other molecules that are important for the survival and function of the cell. As a result, SOAT1 may be a drug target or biomarker for a variety of diseases.

Protein Name: Sterol O-acyltransferase 1

Functions: Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol (PubMed:16154994, PubMed:16647063, PubMed:9020103, PubMed:32433614, PubMed:32433613, PubMed:32944968). Plays a role in lipoprotein assembly and dietary cholesterol absorption (PubMed:16154994, PubMed:9020103). Utilizes oleoyl-CoA ((9Z)-octadecenoyl-CoA) preferentially as susbstrate: shows a higher activity towards an acyl-CoA substrate with a double bond at the delta-9 position (9Z) than towards saturated acyl-CoA or an unsaturated acyl-CoA with a double bond at the delta-7 (7Z) or delta-11 (11Z) positions (PubMed:11294643, PubMed:32433614)

More Common Targets