SORD: Enzyme Involved in Nucleotide Metabolism and Potential Drug Target

Target Name: SORD

NCBI ID: G6652

SORD: Enzyme Involved in Nucleotide Metabolism and Potential Drug Target

SORD (L-iditol (sorbitol) dehydrogenase) is a enzyme that is involved in the metabolism of sugar molecules. It is found in various organisms including bacteria, yeast, and animals. The primary function of SORD is to catalyze the conversion of L-iditol and sorbitol to their respective equine nucleotides, NAD+ and FAD+, respectively.

SORD is a critical enzyme in the metabolism of nucleotides, which are the building blocks of DNA and RNA. It is involved in the biosynthesis of nucleotides from the simple sugars L-iditol and sorbitol, which are found in many organisms. The production of nucleotides from these simple sugars is essential for the growth, development, and survival of all living organisms.

SORD is a transmembrane protein that is expressed in a variety of cell types. It is primarily located in the cytoplasm of cells, but can also be found in the nucleus. SORD is a member of the GPRC gene family, which includes a variety of enzymes involved in the metabolism of nucleotides and other molecules.

SORD has been identified as a potential drug target for the treatment of various diseases. One of the reasons for its potential as a drug target is its involvement in the metabolism of nucleotides, which are involved in many important cellular processes. For example, nucleotides are involved in the regulation of gene expression, DNA replication, and protein synthesis. Therefore, any drug that can affect nucleotide metabolism could potentially have a wide range of therapeutic applications.

In addition to its involvement in nucleotide metabolism, SORD is also involved in the regulation of inflammation and immune responses. It has been shown to be involved in the production of pro-inflammatory cytokines, such as TNF-alpha, IL-1, and IL-6. Therefore, SORD may also be a potential drug target for the treatment of inflammatory diseases.

SORD is a protein that is expressed in many different organisms, including bacteria, yeast, and animals. It is primarily located in the cytoplasm of cells, but can also be found in the nucleus. SORD is a member of the GPRC gene family, which includes a variety of enzymes involved in the metabolism of nucleotides and other molecules. Its involvement in nucleotide metabolism, as well as its potential as a drug target, makes it an important molecule to study in the field of biochemistry and molecular biology.

Protein Name: Sorbitol Dehydrogenase

Functions: Polyol dehydrogenase that catalyzes the reversible NAD(+)-dependent oxidation of various sugar alcohols. Is mostly active with D-sorbitol (D-glucitol), L-threitol, xylitol and ribitol as substrates, leading to the C2-oxidized products D-fructose, L-erythrulose, D-xylulose, and D-ribulose, respectively (PubMed:3365415). Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. The polyol pathway is believed to be involved in the etiology of diabetic complications, such as diabetic neuropathy and retinopathy, induced by hyperglycemia (PubMed:12962626, PubMed:29966615, PubMed:25105142). May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility (PubMed:16278369). May have a more general function in the metabolism of secondary alcohols since it also catalyzes the stereospecific oxidation of (2R,3R)-2,3-butanediol. To a lesser extent, can also oxidize L-arabinitol, galactitol and D-mannitol and glycerol in vitro. Oxidizes neither ethanol nor other primary alcohols. Cannot use NADP(+) as the electron acceptor (PubMed:3365415)

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