SPACA4: A Potential Drug Target and Biomarker (G171169)

Target Name: SPACA4

NCBI ID: G171169

SPACA4: A Potential Drug Target and Biomarker

SPACA4 (SPA-CALC-4) is a gene that encodes a protein known as SPAcalC (SPA-CALC-4), which is expressed in various tissues and cells throughout the body. SPAcalC plays a crucial role in cell signaling, specifically in the regulation of extracellular matrix (ECM) interactions and cytoskeletal organization. Its unique structure and function make it an attractive candidate for drug targeting and research into various diseases.

SPAcalC is composed of 191 amino acid residues, with the first 20 amino acids encoding the extracellular domain. This domain is known for its unique feature of having a constant Asp residue at position 20, which is unusual for a protein that belongs to the calbindin family. The constant Asp residue at position 20 plays a crucial role in the regulation of SPAcalC's stability and functions as a molecular chaperone, helping to maintain its stability in various cellular compartments.

The second 20 amino acids encode the transmembrane domain, which is responsible for SPAcalC's unique structure and function. This domain is characterized by the presence of a unique ring-shaped arrangement of amino acids, known as a calcosmosome, which is responsible for the protein's stability and interactions with other cellular components. Additionally, the transmembrane domain encodes the last 11 amino acids of the extracellular domain, which are involved in the formation of SPAcalC's N-terminus.

SPAcalC's unique structure and function make it an attractive candidate for drug targeting and research into various diseases. One of the main advantages of SPAcalC is its expression in various tissues and cells, which makes it a potential biomarker for various diseases. Its expression is known to be regulated by various factors, including cell signaling pathways, making it an attractive target for small molecules that can modulate its expression and activity.

In addition to its potential as a drug target, SPAcalC has also been shown to be involved in various physiological processes that are important for human health. For example, SPAcalC has been shown to play a role in the regulation of cell adhesion, which is critical for the development and maintenance of tissues and organs. Additionally, SPAcalC has been shown to be involved in the regulation of cell migration, which is essential for the formation of tissues and organs during development and wound healing.

SPAcalC has also been shown to be involved in the regulation of various signaling pathways that are important for human health. For example, SPAcalC has been shown to play a role in the regulation of the TGF-β pathway, which is involved in the regulation of cell growth, differentiation, and inflammation. Additionally, SPAcalC has been shown to play a role in the regulation of the Wnt pathway, which is involved in the regulation of cell growth and development.

In conclusion, SPACA4 (SPA-CALC-4) is a gene that encodes a protein with unique structure and function that makes it an attractive candidate for drug targeting and research into various diseases. Its expression in various tissues and cells, as well as its involvement in various physiological processes and signaling pathways, make it an attractive target for small molecules that can modulate its expression and activity. Further research is needed to determine the full role of SPAcalC in various biological processes and to develop effective small molecules that can modulate its expression and activity.

Protein Name: Sperm Acrosome Associated 4

Functions: Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization

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