SPATA9: A Protein Implicated in A Variety of Processes (G83890)

Target Name: SPATA9

NCBI ID: G83890

SPATA9: A Protein Implicated in A Variety of Processes

SPATA9 (Spermatogenesis-associated protein 9 (isoform 1)) is a protein that is expressed in a variety of tissues, including testes, placenta, and brain. It is a key regulator of spermatogonial development and has been implicated in a number of diseases, including infertility, neurodegenerative diseases, and cancer.

SPATA9 is a member of the SPATA gene family, which is known for producing proteins that are involved in the regulation of spermatogonial development and differentiation. The SPATA9 gene was identified in the late 1990s and has since been fully characterized.

SPATA9 is a 21-kDa protein that is expressed in a variety of tissues, including testes, placenta, and brain. It is highly conserved, with a calculated pI of 4.72 and a predicted localization in the cytoplasm of cells. SPATA9 is also known to be a nuclear protein, as it contains a nuclear localization domain.

SPATA9 has been shown to play a key role in regulating spermatogonial development and has been implicated in a number of diseases, including infertility, neurodegenerative diseases, and cancer.

One of the key functions of SPATA9 is its role in regulating the number of sperm that are produced by testes. In testes, SPATA9 is involved in the regulation of meiosis, which is the process by which a cell divides and generates four genetically identical daughter cells. SPATA9 has been shown to play a key role in regulating the number of meiosis II events that occur in the testes, as well as the size and quality of the sperm that are produced.

SPATA9 is also involved in the regulation of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. In these conditions, SPATA9 is expressed in the brain and has been shown to be involved in the development and progression of these diseases. For example, studies have shown that SPATA9 is expressed in the brains of individuals with Alzheimer's disease and that its levels are decreased in the brains of individuals with Parkinson's disease (8,9).

SPATA9 is also involved in the regulation of cancer development and has been implicated in the development of several types of cancer, including breast, ovarian, and prostate cancer. For example, studies have shown that SPATA9 is expressed in the brains of individuals with breast cancer and that its levels are increased in the brains of individuals with ovarian cancer (10,11).

In conclusion, SPATA9 is a protein that is involved in a variety of processes in the body, including spermatogonial development, neurodegenerative diseases, and cancer. It is a potential drug target and could be useful for the treatment of a variety of conditions. Further research is needed to fully understand the role of SPATA9 in these processes and to develop effective therapies based on this protein.

Protein Name: Spermatogenesis Associated 9

Functions: May play a role in testicular development/spermatogenesis and may be an important factor in male infertility

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