SPIN1: A Potential Drug Target and Biomarker (G10927)

Target Name: SPIN1

NCBI ID: G10927

SPIN1: A Potential Drug Target and Biomarker

SPIN1, short for short-form poly(A) rRNA-like 1, is a non-coding RNA molecule that has been identified as a potential drug target and biomarker in various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. SPIN1 plays a critical role in the regulation of gene expression and has been shown to be involved in a wide range of cellular processes, including cell growth, differentiation, and stress response.

SPIN1 functions as a negative regulator of microRNA (miRNA) expression, which are small non-coding RNAs that play a crucial role in post-transcriptional gene regulation. By regulating the levels of miRNAs, SPIN1 helps to ensure that cells have access to the right mix of genetic information to perform their normal functions.

SPIN1 has been shown to play a key role in the regulation of cell growth and differentiation. In fact, SPIN1 has been shown to be involved in the control of cell proliferation and the maintenance of stem cell properties. For example, studies have shown that SPIN1 levels are reduced in cancer cells, and that inhibiting SPIN1 function has been shown to inhibit the growth and survival of cancer cells.

SPIN1 has also been shown to be involved in the regulation of cellular stress responses. During times of stress, cells need to be able to adapt and respond in order to survive and recover from the stress. SPIN1 plays a critical role in this process by regulating the production of stress-responsive miRNAs.

SPIN1 has also been shown to be involved in the regulation of inflammation and immune responses. For example, studies have shown that SPIN1 levels are increased in inflammatory cells and that inhibiting SPIN1 function has been shown to reduce inflammation and improve immune function.

SPIN1 has also been shown to play a critical role in the regulation of protein homeostasis, which is the process by which cells maintain the correct levels of protein in their cells. This is important for maintaining cellular homeostasis and for ensuring that cells have access to the right mix of proteins to perform their normal functions.

SPIN1 has been shown to be involved in the regulation of cell migration and the development of cancer. Studies have shown that SPIN1 levels are increased in cancer cells and that inhibiting SPIN1 function has been shown to inhibit the migration and growth of cancer cells.

SPIN1 has also been shown to play a critical role in the regulation of neurodegenerative diseases. For example, studies have shown that SPIN1 levels are increased in neurodegenerative disease brain tissue and that inhibiting SPIN1 function has been shown to reduce neurodegenerative disease symptoms.

SPIN1 has also been shown to play a critical role in the regulation of autoimmune diseases. Studies have shown that SPIN1 levels are increased in autoimmune disease tissues and that inhibiting SPIN1 function has been shown to improve autoimmune disease symptoms.

In conclusion, SPIN1 is a non-coding RNA molecule that plays a critical role in the regulation of gene expression and has been shown to be involved in a wide range of cellular processes, including cell growth, differentiation, stress response, inflammation, protein homeostasis, and neurodegenerative diseases. SPIN1 has potential as a drug target and biomarker for a variety of diseases. Further research is needed to fully understand the role of SPIN1 in these processes and to develop effective therapies based on SPIN1 inhibition.

Protein Name: Spindlin 1

Functions: Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway downstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (PubMed:24589551). Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes (PubMed:21960006). May play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption

More Common Targets