SPIRE1: A Protein Implicated in Cancer and Other Diseases (G56907)

Target Name: SPIRE1

NCBI ID: G56907

SPIRE1: A Protein Implicated in Cancer and Other Diseases

SPIRE1 (SPIR1_HUMAN) is a protein that is expressed in various tissues of the human body. It is a key regulator of the immune response and has been implicated in a number of diseases, including cancer. As a drug target or biomarker, SPIRE1 has significant potential for the development of new treatments for a variety of diseases.

SPIRE1 is a protein that is expressed in the cytoplasm of various cell types, including immune cells, epithelial cells, and muscle cells. It is a key regulator of the immune response, and is involved in the development and regulation of T cells, B cells, and natural killer cells. SPIRE1 has been shown to play a role in the regulation of immune cell function, and is a potential target for drugs that can modulate the immune response.

In addition to its role in immune regulation, SPIRE1 is also involved in the regulation of cell survival and metabolism. It has been shown to play a role in the regulation of cell cycle progression, and is involved in the development and maintenance of cancer cells. As a drug target or biomarker, SPIRE1 may be useful in the development of new treatments for cancer.

SPIRE1 has also been shown to be involved in the regulation of inflammation. It has been shown to play a role in the regulation of inflammatory cytokine production and the recruitment of immune cells to the site of inflammation. As a drug target or biomarker, SPIRE1 may be useful in the development of new treatments for inflammatory diseases.

SPIRE1 is also involved in the regulation of cell adhesion and signaling. It has been shown to play a role in the regulation of cell-cell adhesion and the signaling of signaling pathways that are involved in cell growth, differentiation, and survival. As a drug target or biomarker, SPIRE1 may be useful in the development of new treatments for diseases that are characterized by disrupted cell-cell signaling.

In conclusion, SPIRE1 (SPIR1_HUMAN) is a protein that is expressed in various tissues of the human body and is involved in a number of important biological processes, including immune regulation, cell survival and metabolism, inflammation, and cell adhesion and signaling. As a drug target or biomarker, SPIRE1 has significant potential for the development of new treatments for a variety of diseases. Further research is needed to fully understand the role of SPIRE1 in human biology and to develop effective treatments based on this protein.

Protein Name: Spire Type Actin Nucleation Factor 1

Functions: Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament (PubMed:11747823, PubMed:21620703). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (PubMed:11747823). Required for asymmetric spindle positioning and asymmetric cell division during meiosis (PubMed:21620703). Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis (PubMed:21620703). Also acts in the nucleus: together with FMN2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). In addition, promotes innate immune signaling downstream of dsRNA sensing (PubMed:35148361). Mechanistically, contributes to IRF3 phosphorylation and activation downstream of MAVS and upstream of TBK1 (PubMed:35148361)

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