SPTAN1: A Protein Implicated in Alzheimer's Disease (G6709)

Target Name: SPTAN1

NCBI ID: G6709

SPTAN1: A Protein Implicated in Alzheimer's Disease

SPTAN1 (SPTA2) is a protein that is expressed in the brain and is known for its role in the development and progression of several neurological disorders, including Alzheimer's disease. The protein is a key player in the so-called \"endoplasmic reticulum-associated protein\" (ERP) family, which includes a variety of proteins that are involved in the transport and processing of proteins in the brain.

SPTAN1 is a 21-kDa protein that is expressed in the brain and is highly conserved across different species, including humans. It is localized to the endoplasmic reticulum, where it is involved in the processing and quality control of proteins before they are transported to the plasma membrane.

SPTAN1 is one of several proteins in the ERP family that have been implicated in the development and progression of Alzheimer's disease. Studies have shown that SPTAN1 levels are significantly reduced in the brains of individuals with Alzheimer's disease compared to age-matched control individuals. Additionally, genetic studies have identified several variants of the SPTAN1 gene that are associated with an increased risk of developing Alzheimer's disease.

In addition to its role in the development of Alzheimer's disease, SPTAN1 is also a potential drug target. Studies have shown that SPTAN1 is involved in the formation of neurofibrillary tangles, which are a hallmark of Alzheimer's disease. Additionally, SPTAN1 has been shown to interact with several other proteins that are involved in the development and progression of Alzheimer's disease, including tau, a protein that is known to contribute to the development of neurofibrillary tangles.

SPTAN1 is also a potential biomarker for the diagnosis and monitoring of Alzheimer's disease. Studies have shown that SPTAN1 levels can be used as a reliable biomarker for the early detection of Alzheimer's disease, with levels of the protein declining significantly over the course of the disease. Additionally, SPTAN1 has been shown to be highly stable over the course of several years, which could make it a useful long-term biomarker for the disease.

In conclusion, SPTAN1 is a protein that is involved in the development and progression of Alzheimer's disease. Its role in the ERP family and its involvement in the formation of neurofibrillary tangles make it a potential drug target. Additionally, its potential as a biomarker for the early detection and monitoring of Alzheimer's disease make it an attractive target for future research. Further studies are needed to fully understand the role of SPTAN1 in the development and progression of Alzheimer's disease and to develop effective treatments.

Protein Name: Spectrin Alpha, Non-erythrocytic 1

Functions: Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane

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