SSB Protein: A Potential Target for Cellular Signaling and Biomarker Development

Target Name: SSB

NCBI ID: G6741

SSB Protein: A Potential Target for Cellular Signaling and Biomarker Development

SSB (SS-B/La protein) is a protein that is expressed in various tissues throughout the body, including the brain, heart, and kidneys. It is a member of the SS family of proteins, which are known for their role in intracellular signaling. While the exact function of SSB protein is not yet fully understood, it is possible that it plays a role in the regulation of cellular processes such as cell growth, differentiation, and survival.

One of the unique features of SSB protein is its ability to interact with a variety of different molecules. This allows it to be involved in a wide range of cellular processes, making it an attractive target for researchers looking for new drugs or biomarkers. For example, SSB has been shown to interact with a variety of signaling molecules, including TGF-β, PDGF, and NF-kappa-B. This suggests that it may be involved in the regulation of cellular processes that are influenced by these signaling pathways.

Another potential mechanism by which SSB may be involved in cellular signaling is its role in the regulation of protein synthesis. SSB is known to interact with the protein translation factor SSAP, which is involved in the delivery of new proteins to the endoplasmic reticulum. This suggests that SSB may be involved in the regulation of the translation of new proteins into the cell, potentially serving as a drug target for diseases characterized by the overproduction or underproduction of certain proteins.

In addition to its potential role in cellular signaling, SSB protein is also of interest as a potential biomarker. The over-expression of SSB protein has been shown to be associated with a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. This suggests that SSB may be a useful diagnostic or therapeutic target for these diseases.

Furthermore, the structure and function of SSB protein are also of interest. The SSB protein is composed of a single polypeptide chain that is approximately 150 amino acids long. It has a characteristic Rossmann-fold, which is a type of hydrogen bonding that is involved in the formation of a stable beta-sheet structure. This structure is thought to give SSB protein its unique stability and stability, allowing it to function in a variety of cellular contexts.

In conclusion, SSB protein is an attractive target for research into the regulation of cellular processes and as a potential biomarker for a variety of diseases. Further studies are needed to fully understand its function and its potential as a drug or biomarker.

Protein Name: Small RNA Binding Exonuclease Protection Factor La

Functions: Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation (PubMed:3192525, PubMed:2470590). In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12384597)

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