ST6GALNAC6: A Drug Target / Disease Biomarker (G30815)

Target Name: ST6GALNAC6

NCBI ID: G30815

Other Name(s): ST6GalNAc VI | Sialyltransferase 7F | OTTHUMP00000022211 | HST6GalNAc VI | OTTHUMP00000022210 | SIAT7-F | sialyltransferase 7F | epididymis secretory sperm binding protein | SIAT7F | Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 (isoform a) | ST6GalNAcVI | galNAc alpha-2,6-sialyltransferase VI | ST6GALNAC6 variant 1 | ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6, transcript variant 1 | Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 | Sialytransferase 7 ((alpha-N-acetylneuraminyl 2,3-betagalactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialytransferase) F | hST6GalNAc VI | SIA7F_HUMAN | GalNAc alpha-2,6-sialyltransferase VI | RP11-203J24.3 | ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 | sialytransferase 7 ((alpha-N-acetylneuraminyl 2,3-betagalactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialytransferase) F | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 | ST6 -N-acetylgalactosaminide alpha-26-sialyltransferase 6 | ST6GALNACVI | ST6 GalNAc alpha-2,6-sialyltransferase 6 | CMP-NeuAC:(beta)-N-acetylgalactosaminide (alpha)2,6-sialyltransferase member VI

ST6GALNAC6: A Drug Target / Disease Biomarker

ST6GALNAC6 is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a member of the GALNAC6 family, which is known for its role in cell signaling. ST6GALNAC6 has been shown to play a role in a variety of physiological processes, including cell growth, differentiation, and inflammation. As a result, ST6GALNAC6 has potential as a drug target or biomarker.

One of the unique features of ST6GALNAC6 is its structure. It is a transmembrane protein that consists of an extracellular domain, a transmembrane domain, and an intracellular domain. The transmembrane domain is responsible for the protein's ability to interact with other cells and molecules. The intracellular domain is responsible for the protein's ability to interact with inside the cell.

ST6GALNAC6 has been shown to play a role in a variety of physiological processes, including cell growth, differentiation, and inflammation. For example, studies have shown that ST6GALNAC6 is involved in the regulation of cell growth and differentiation. In addition, ST6GALNAC6 has been shown to play a role in the regulation of inflammation.

Another unique feature of ST6GALNAC6 is its expression. It is expressed in a variety of tissues, including the brain, heart, and kidneys. This makes it a potential drug target or biomarker that can be targeted by drugs that are designed to modulate its expression or activity.

In conclusion, ST6GALNAC6 is a protein that has potential as a drug target or biomarker. Its unique structure and expression make it an attractive target for drug development. Further research is needed to fully understand its role in physiological processes and its potential as a drug.

Protein Name: ST6 N-acetylgalactosaminide Alpha-2,6-sialyltransferase 6

Functions: Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc onto glycoproteins and glycolipids, forming an alpha-2,6-linkage. Produces branched type disialyl structures by transfer of a sialyl group onto the GalNAc or GlcNAc residue inside backbone core chains having a terminal sialic acid with an alpha-2,3-linkage on Gal. ST6GalNAcVI prefers glycolipids to glycoproteins, predominantly catalyzing the biosynthesis of ganglioside GD1alpha from GM1b (PubMed:12668675, PubMed:17123352). Besides GMb1, MSGG and other glycolipids, it shows activity towards sialyl Lc4Cer generating disialyl Lc4Cer, which can lead to the synthesis of disialyl Lewis a (Le(a)), suggested to be a cancer-associated antigen (PubMed:12668675). Also has activity toward GD1a and GT1b, and can generate DSGG (disialylgalactosylgloboside) from MSGG (monosialylgalactosylgloboside) (By similarity)

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