STK24: A Potential Drug Target for Cancer (G8428)

Target Name: STK24

NCBI ID: G8428

STK24: A Potential Drug Target for Cancer

STK24, also known as Serine/Threonine Kinase 24 (STE20 homolog, yeast), is a protein that is expressed in various cell types, including neurons, muscle cells, and cancer cells. It plays a crucial role in the regulation of cell signaling pathways, particularly in the process of cell growth, differentiation, and survival. Unfortunately, STK24 has also been identified as a potential drug target and has been studied extensively in the context of various diseases, including cancer.

The STK24 protein is composed of 214 amino acid residues and has a molecular weight of 23.2 kDa. It is a serine kinase, which means that it uses serine as its catalytic reagent to convert other amino acids into reactive derivatives. STK24 is a potent inhibitor of the protein kinase B-type, which is involved in cell signaling pathways. This is remarkable, as B-type protein kinases are often targeted by drugs in the clinic for the treatment of various diseases.

STK24 has been shown to play a critical role in the regulation of cell growth and differentiation. In studies using cell culture models, it has been shown that STK24 inhibits the growth of cancer cells in a variety of models, including the inhibition of cell cycle progression, apoptosis, and angiogenesis. This suggests that STK24 may be an effective target for cancer therapies.

Furthermore, STK24 has also been shown to be involved in the regulation of cell survival. In studies using animal models of cancer, it has been shown that STK24 knockdown has a significant impact on the survival of cancer cells, with a reduction in cell survival rate. This suggests that STK24 may be a useful biomarker for cancer diagnosis and treatment.

In addition to its role in cell survival, STK24 has also been shown to play a critical role in the regulation of cell signaling pathways. In studies using cell signaling assays, it has been shown that STK24 interacts with various signaling molecules, including TGF-β, NF-kappa-B, and MAPK/ERK. These interactions suggest that STK24 may be involved in the regulation of cellular processes that are critical for cancer progression.

Given the potential implications of STK24 as a drug target and its involvement in cell signaling pathways, there is ongoing research into the use of STK24 as a therapeutic agent. Studies are being conducted to investigate the efficacy and safety of STK24-targeted therapies in cancer models, with the goal of identifying new treatments for various diseases.

In conclusion, STK24 is a protein that has been shown to play a critical role in the regulation of cell signaling pathways and has been identified as a potential drug target for cancer therapies. Its role in cell growth, differentiation, and survival makes it an attractive target for small molecule inhibitors. Further research is needed to investigate the efficacy and safety of STK24-targeted therapies in cancer models, with the goal of identifying new treatments for various diseases.

Protein Name: Serine/threonine Kinase 24

Functions: Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. In association with STK26 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation (PubMed:27807006). Regulates also cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve

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