STRN4: A Protein of Interest for Drug Targets and Biomarkers (G29888)

Target Name: STRN4

NCBI ID: G29888

STRN4: A Protein of Interest for Drug Targets and Biomarkers

STRN4 (zinedin) is a protein that is expressed in various tissues throughout the body, including the brain, heart, and kidneys. It is a member of the ZNF2 gene family, which is known for its role in regulating neural development and function.

One of the unique features of STRN4 is its ability to form aggregates in the brain, which are thought to play a role in the development and progression of certain neurological conditions. For example, individuals with Alzheimer's disease have been shown to have increased levels of STRN4 in their brains, and research has suggested that inhibiting the activity of this protein may be a potential treatment for this disease.

In addition to its role in neurological development, STRN4 has also been shown to play a key role in the regulation of blood pressure. This is because the protein is expressed in the smooth muscle cells of the blood vessels, and it has been shown to regulate the contractions of these cells. This may be important for maintaining a healthy blood pressure, as high blood pressure can lead to a number of health problems, including heart disease and stroke.

Another potential drug target for STRN4 is its role in the regulation of stem cell proliferation. The ZNF2 gene family has been shown to play a key role in the regulation of stem cell proliferation, and this may be important for the development of cancer. Therefore, inhibiting the activity of STRN4 may be a potential treatment for cancer.

In addition to its potential drug targets, STRN4 is also of interest as a biomarker for certain diseases. For example, the levels of STRN4 have been shown to be elevated in the brains of individuals with Parkinson's disease, and this may be an indication that the protein is involved in the development and progression of this disease. Similarly, the levels of STRN4 have been shown to be elevated in the blood vessels of individuals with heart disease, and this may be an indication that the protein is involved in the regulation of blood pressure.

Overall, STRN4 is a protein that is expressed in various tissues throughout the body and is thought to play a role in the regulation of neural development and function, blood pressure, and stem cell proliferation. As such, it is of interest as a potential drug target and as a biomarker for certain diseases. Further research is needed to fully understand the role of STRN4 in these processes and to develop effective treatments for the associated conditions.

Protein Name: Striatin 4

Functions: Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein

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