SUCNR1: A GPCR Regulating Pain Perception and Neurotransmitter Release

Target Name: SUCNR1

NCBI ID: G56670

SUCNR1: A GPCR Regulating Pain Perception and Neurotransmitter Release

SUCNR1 (GPR91) is a G protein-coupled receptor (GPCR) that is expressed in various tissues and cells in the body. It is a key regulator of neural development, plasticity, and pain perception. GPCRs are a family of transmembrane proteins that play a crucial role in cellular signaling, and they are involved in a wide range of physiological processes, including sensory perception, neurotransmitter signaling, and cell survival.

SUCNR1 is a GPCR that is expressed in the nervous system, including the brain, spinal cord, and peripheral tissues. It is highly homozygous in humans, and its function is poorly understood.SUCNR1 has been shown to play a role in pain perception and neurotransmitter release, and it is a potential drug target in the treatment of pain and neurodegenerative diseases.

One of the key functions of SUCNR1 is its role in pain perception is as a negative modulator of pain signaling. Pain is a complex cellular signaling event that involves the release of pro-inflammatory cytokines, neurotransmitters, and other signaling molecules.SUCNR1 has been shown to play a role in the regulation of pain signaling by suppressing the release of these molecules.

SUCNR1 has been shown to regulate the activity of various neurotransmitter systems, including the opioid system, which is involved in the treatment of pain. The opioid system is composed of opioid receptors, which are involved in the perception and treatment of pain.SUCNR1 has been shown to regulate the activity of opioid receptors by blocking the activity of GPCRs, which would normally activate these receptors and contribute to pain perception.

Another function of SUCNR1 is its role in neurotransmitter release.SUCNR1 has been shown to play a role in the regulation of neurotransmitter release by interacting with the neurotransmitter receptor, 尾2 (尾2AR) which is involved in the regulation of anxiety and mood.SUCNR1 has been shown to regulate the activity of 尾2AR by interacting with its extracellular domain, which is involved in the regulation of neurotransmitter release.

In addition to its role in pain perception and neurotransmitter release, SUCNR1 is also involved in the regulation of cellular signaling.SUCNR1 has been shown to play a role in the regulation of cellular signaling by interacting with various signaling pathways, including the TGF-β pathway, which is involved in cell growth and survival.

SUCNR1 is a potential drug target for the treatment of pain and neurodegenerative diseases.SUCNR1 has been shown to be involved in the regulation of pain perception, neurotransmitter release, and cellular signaling, and these functions are important for the treatment of pain and neurodegenerative diseases.Further studies are needed to fully understand the function of SUCNR1 and its potential as a drug target.

Protein Name: Succinate Receptor 1

Functions: Receptor for succinate

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