SUPT4H1: A Potential Drug Target for Disorders (G6827)

Target Name: SUPT4H1

NCBI ID: G6827

SUPT4H1: A Potential Drug Target for Disorders

SUPT4H1, also known as DSIF small subunit, is a protein that is expressed in various tissues throughout the body. It is a key regulator of the cell division process, and is involved in the development and maintenance of tissues such as brain, heart, and muscle.

Recent studies have identified SUPT4H1 as a potential drug target and biomarker for a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. This is because the protein is involved in many cellular processes that are important for the development and progression of these diseases, and may be a useful target for therapies that can inhibit its activity.

One of the key functions of SUPT4H1 is its role in the regulation of cell division. It is a critical regulator of the mitotic spindle, which is the structure that pulls the chromosomes apart during cell division and ensures that they are properly segregated.SUPT4H1 is involved in the formation of the spindle and in the maintenance of its stability, which is essential for proper chromosome segregation.

In addition to its role in cell division, SUPT4H1 is also involved in the regulation of the cytoskeleton. The cytoskeleton is the structure that gives cells shape and stability, and is important for many cellular processes, including cell division, migration, and storage of organelles.SUPT4H1 is involved in the regulation of the cytoskeleton by controlling the assembly and disassembly of microtubules, which are the structural elements that make up the cytoskeleton.

Another function of SUPT4H1 is its role in the regulation of cell signaling pathways.SUPT4H1 is involved in a variety of signaling pathways, including those that regulate cell growth, differentiation, and survival. It is also involved in the regulation of angiogenesis, the formation of new blood vessels, which is important for many diseases, including cancer.

In conclusion, SUPT4H1 is a protein that plays a critical role in the regulation of cell division, cytoskeleton and cell signaling pathways. As a potential drug target and biomarker, SUPT4H1 is a promising target for the development of new therapies for a variety of diseases.

Protein Name: SPT4 Homolog, DSIF Elongation Factor Subunit

Functions: Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences

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