SULF2: A Drug Target and Biomarker for treatable Brain Disorders

Target Name: SULF2

NCBI ID: G55959

SULF2: A Drug Target and Biomarker for treatable Brain Disorders

Sulfatase 2 (SULF2) is a protein that plays a crucial role in the development and progression of various neurological disorders, including neurodegenerative diseases. The SULF2 gene has been associated with a range of neurodevelopmental and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia. Therefore, targeting SULF2 has the potential to provide new treatments for these debilitating conditions.

SULF2 functions as a dipeptidases, breaking down a specific protein called keratin into smaller peptides. Keratin is the main component of tissues such as hair, skin and feathers. Under normal circumstances, keratin catabolism is a key process for maintaining tissue growth and repair. However, when keratin catabolism is abnormal, such as in neurodegenerative diseases, it can lead to neuronal damage and death, ultimately leading to disease progression.

Abnormal expression of SULF2 is closely related to the occurrence and development of neurodegenerative diseases. Studies have found that overexpression or deletion of SULF2 is a key factor in the development of neurodegenerative diseases. In addition, abnormal expression of SULF2 can also lead to neuronal damage and apoptosis, thereby aggravating the progression of the disease.

In addition to its relationship with neurodegenerative diseases, SULF2 has also been linked to mental health. For example, overexpression or deletion of SULF2 is associated with the development of mental disorders such as depression and anxiety. Therefore, SULF2 is considered a potential drug target.

To better understand the function and pharmacology of SULF2, researchers have conducted extensive studies. These studies have revealed a lot of important information about SULF2, including its structure, function, regulatory mechanisms, and relevance to diseases.

First, the structure and function of SULF2 were determined experimentally. SULF2 is a 21 kDa polypeptide with a single polypeptide chain. It contains two conserved cysteine 鈥嬧?媟esidues that can undergo sulfation modification. Sulfation modification of acidic cysteine 鈥嬧?媟esidues of SULF2 is key to SULF2 function as it can affect its structure and function.

Second, the function of SULF2 was determined experimentally. SULF2 is a keratinase that hydrolyzes keratin. Under normal circumstances, the hydrolysis of SULF2 is key to maintaining hair growth and repair processes. However, when SULF2 becomes abnormal, such as in neurodegenerative diseases, it can cause damage to the hair and scalp, ultimately leading to disease progression. Therefore, overexpression or deletion of SULF2 is associated with the development of neurodegenerative diseases.

In addition, the regulatory mechanism of SULF2 has also been revealed. SULF2 function can be regulated in multiple ways, including gene expression, protein modification, and intracellular localization. These regulatory mechanisms can affect the activity of SULF2, thereby affecting its function.

Finally, the relationship between SULF2 and disease has also been revealed. Overexpression or loss of SULF2 is associated with the development of neurodegenerative diseases, mental disorders, and skin diseases. Therefore, SULF2 is a potential drug target.

Taken together, SULF2 is a potential drug target for the treatment of neurodegenerative diseases, mental disorders, and skin diseases. By inhibiting the function of SULF2, the progression of the disease can be slowed or stopped, providing new treatments for patients.

Protein Name: Sulfatase 2

Functions: Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity (PubMed:12368295, PubMed:30788513, PubMed:35294879). It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin (PubMed:12368295, PubMed:30788513, PubMed:35294879)

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