Sulfotransferase 1A4: Druggable Protein with Multiple Functions

Target Name: SULT1A4

NCBI ID: G445329

Sulfotransferase 1A4: Druggable Protein with Multiple Functions

Sulfotransferase 1A4 (SULT1A4) is a protein that is expressed in various tissues throughout the body, including the brain, heart, liver, and kidneys. It plays a crucial role in the regulation of cell signaling and metabolism.

SULT1A4 is a member of the superfamily of transmembrane proteinases known as the sulfotransferases. These proteins are characterized by their ability to transfer sulfur groups from the cytoplasm to the cell surface. SULT1A4 is specific for its ability to transfer sulfur groups to the protein p120, which is a type of transcription factor that plays a role in cell signaling and metabolism.

SULT1A4 is involved in a wide range of cellular processes, including cell signaling, DNA replication, and metabolism. It has been shown to play a role in the regulation of cell proliferation, differentiation, and apoptosis.

One of the unique features of SULT1A4 is its ability to form a complex with other proteins, including p120. This complex plays a role in the regulation of cellular processes such as cell signaling, DNA replication, and metabolism.

SULT1A4 has also been shown to play a role in the regulation of metabolism. It has been shown to play a role in the metabolism of fats and in the regulation of insulin sensitivity.

In addition to its role in metabolism, SULT1A4 has also been shown to play a role in the regulation of cell signaling. It has been shown to play a role in the regulation of cell proliferation and differentiation, as well as in the regulation of cell adhesion.

SULT1A4 has also been shown to play a role in the regulation of cell death. It has been shown to play a role in the regulation of cell apoptosis, as well as in the regulation of cell necrosis.

SULT1A4 has also been shown to play a role in the regulation of the immune response. It has been shown to play a role in the regulation of inflammation and immune cell function.

In conclusion, SULT1A4 is a protein that is involved in a wide range of cellular processes, including cell signaling, DNA replication, and metabolism. Its unique ability to form a complex with other proteins, including p120, makes it a potential drug target and biomarker. Further research is needed to fully understand the role of SULT1A4 in cellular processes and its potential as a drug.

Protein Name: Sulfotransferase Family 1A Member 4

Functions: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, norepinephrine and serotonin) and phenolic and catechol drugs

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