Sulfotransferase 1E Member 1: A Potential Drug Target for Xenobiotics and Cellular Signaling

Target Name: SULT1E1

NCBI ID: G6783

Sulfotransferase 1E Member 1: A Potential Drug Target for Xenobiotics and Cellular Signaling

Sulfotransferase family 1E member 1 (SULT1E1) is a enzyme that plays a crucial role in the detoxification of xenobiotics, such as drugs, pesticides, and other harmful substances in the human body. The SULT1E1 enzyme is an essential protein that is expressed in many different tissues throughout the body, including the liver, kidney, and muscle.

Sulfotransferase family 1E member 1 (SULT1E1) is a member of the Sulfotransferase family, which is a large superfamily of enzymes that are involved in the transfer of sulfur groups from one molecule to another. This family of enzymes includes other well-known enzymes, such as the hereditary sulfur transferase enzymes, which are involved in the detoxification of organic acids, and the 2-redoxase enzymes, which are involved in the detoxification of xenobiotics.

SULT1E1 is a monoclonal antibody, which means that it is a single, isolated molecule that is produced by a cell in the laboratory. This makes it unique from other proteins, which are often made in bulk by cell cultures or animals. Monoclonal antibodies have several advantages over other proteins, including the ability to be highly specific for target molecules, the ability to be easily modified and optimized for specific applications, and the ability to be produced in large quantities.

SULT1E1 has been shown to be involved in the detoxification of a wide variety of xenobiotics, including drugs, pesticides, and other harmful substances. For example, studies have shown that SULT1E1 is involved in the detoxification of the neurotoxin BMI (尾-methylisothiocyanate), which is a toxic compound that can cause damage to the brain and nervous system.

In addition to its role in the detoxification of xenobiotics, SULT1E1 has also been shown to have other important functions in the body. For example, it is involved in the regulation of cellular signaling pathways, which are responsible for transmitting signals from cells to other cells and for maintaining the structure and function of tissues. SULT1E1 has also been shown to play a role in the regulation of inflammation, which is important for maintaining the health and integrity of tissues.

SULT1E1 is also a potential drug target, which means that it is a target for therapeutic intervention. This is because its involvement in the detoxification of xenobiotics and its other important functions in the body make it an attractive target for drugs that are designed to promote health and prevent disease. For example, drugs that are designed to disrupt SULT1E1 activity have been shown to be effective in treating a variety of conditions, including cancer, neurodegenerative diseases, and autoimmune disorders.

In conclusion, sulfotransferase family 1E member 1 (SULT1E1) is an essential enzyme that plays a crucial role in the detoxification of xenobiotics and other harmful substances in the human body. Its unique monoclonal antibody properties and its involvement in the regulation of cellular signaling pathways and inflammation make it an attractive target for therapeutic intervention. Further research is needed to fully understand the role of SULT1E1 in the detoxification of xenobiotics and its potential as a drug target.

Protein Name: Sulfotransferase Family 1E Member 1

Functions: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone (PubMed:7779757, PubMed:11884392, PubMed:11006110). Is a key enzyme in estrogen homeostasis, the sulfation of estrogens leads to their inactivation. Also sulfates dehydroepiandrosterone (DHEA), pregnenolone, (24S)-hydroxycholesterol and xenobiotic compounds like ethinylestradiol, equalenin, diethyl stilbesterol and 1-naphthol at significantly lower efficiency (PubMed:11006110, PubMed:19589875). Does not sulfonate cortisol, testosterone and dopamine (PubMed:7779757, PubMed:11006110). May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system

More Common Targets