SULT1C4: A Critical Regulator of Cell Signaling and Processes

Target Name: SULT1C4

NCBI ID: G27233

SULT1C4: A Critical Regulator of Cell Signaling and Processes

SULT1C4, also known as sulfotransferase family 1 member 2, is a protein that is expressed in a variety of tissues throughout the body. It is a cytosolic protein that is localized to the endoplasmic reticulum (ER) and the nuclear envelope (NE). SULT1C4 plays a critical role in the regulation of various cellular processes, including cell signaling, DNA replication, and protein synthesis.

SULT1C4 is a member of the sulfotransferase family, which is a large superfamily of enzymes that transfer sulfur groups from various donors to acceptors. This family includes enzymes that are involved in a wide range of cellular processes, including DNA replication, transcription, and translation. SULT1C4 is characterized by its unique catalytic mechanism, which involves the transfer of a sulfur group from the substrate protein to acceptor protein via a protein-protein interaction.

SULT1C4 is expressed in a variety of tissues throughout the body, including the liver, heart, kidneys, and pancreas. It is also expressed in various cell types, including muscle cells, nerve cells, and epithelial cells. SULT1C4 plays a critical role in the regulation of various cellular processes, including cell signaling, DNA replication, and protein synthesis.

One of the key functions of SULT1C4 is its role in DNA replication. SULT1C4 is involved in the regulation of DNA replication by the enzyme DNA polymerase. DNA polymerase is a critical enzyme that is involved in the replication of DNA in the cell. SULT1C4 plays a critical role in the regulation of DNA polymerase activity by the substrate protein, which allows it to efficiently transfer the sulfur group from the substrate protein to the acceptor protein.

SULT1C4 is also involved in the regulation of protein synthesis. It is a critical regulator of the translation of proteins into the cell, which is the process by which proteins are synthesized from the amino acids. SULT1C4 plays a critical role in the regulation of protein synthesis by the substrate protein, which allows it to efficiently transfer the sulfur group from the substrate protein to the acceptor protein.

In addition to its role in DNA replication and protein synthesis, SULT1C4 is also involved in the regulation of cell signaling. It is a critical regulator of the signaling pathway that regulates cell growth, differentiation, and survival. SULT1C4 plays a critical role in the regulation of this pathway by the substrate protein, which allows it to efficiently transfer the sulfur group from the substrate protein to the acceptor protein.

SULT1C4 is also involved in the regulation of cell adhesion. It is a critical regulator of cell adhesion by the process of cadherin-mediated cell-cell adhesion. SULT1C4 plays a critical role in the regulation of this process by the substrate protein, which allows it to efficiently transfer the sulfur group from the substrate protein to the acceptor protein.

SULT1C4 is also involved in the regulation of cell signaling. It is a critical regulator of the signaling pathway that regulates cell growth, differentiation, and survival. SULT1C4 plays a critical role in the regulation of this pathway by the substrate protein, which allows it to efficiently transfer the sulfur group from the substrate protein to the acceptor protein.

In conclusion, SULT1C4 is a critical regulator of various cellular processes that are essential for the survival and proper functioning of the cell. It is a cytosolic protein that is localized to the endoplasmic reticulum and the nuclear envelope and plays a critical role in the regulation of DNA replication, protein synthesis, cell signaling, and cell adhesion. As a potential drug target or biomarker, SULT1C4 is a promising target for the development of new therapies for a variety of diseases.

Protein Name: Sulfotransferase Family 1C Member 4

Functions: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic compounds. Can also sulfonate estrogenic compounds, however, the dietary flavonoids (phytoestrogen) and environmental estrogens, like bisphenol A are better substrates than 17beta-estradiol (E2) (PubMed:17425406, PubMed:28222028, PubMed:9852044, PubMed:26948952). Mediates the sulfation of doxorubicin and its analog epirubicin, two antitumor anthracyclines (PubMed:26948952)

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