SULF1: A Protein Involved in Sulfate Regulation (G23213)

Target Name: SULF1

NCBI ID: G23213

SULF1: A Protein Involved in Sulfate Regulation

SULF1, or sulfatase 1, is a protein that is expressed in various cell types throughout the body. It plays a critical role in the regulation of sulfate levels in the body, which are essential for many cellular processes. SULF1 is often used as a drug target or biomarker because of its unique structure and function.

The SULF1 protein is composed of 214 amino acid residues and has a molecular weight of 23.1 kDa. It is localized to the endoplasmic reticulum, which is the system for transporting proteins from the cell body to the membrane of the endoplasmic reticulum. SULF1 is also known as transthyretin sulfate synthase, or TTS, because it is involved in the synthesis of sulfate from the amino acids that make up tetrathionein, a protein that is involved in the production of red blood cells.

SULF1 is a key enzyme in the regulation of sulfate levels in the body. It catalyzes the conversion of the amino acids cysteine and glutamic acid to cysteine sulfate and glutamic acid, respectively. This conversion is critical for the production of tetrathionein, which is a protein that is involved in the production of red blood cells, nerve function, and many other cellular processes.

SULF1 is also involved in the regulation of other sulfate-containing molecules in the body. For example, it is involved in the synthesis of sulfate from the amino acids lysine and arginine, which are important for the structure and function of proteins. It is also involved in the detoxification of sulfate, which is harmful to the body if it becomes too much.

SULF1 is a protein that is expressed in many different cell types throughout the body, including red blood cells, white blood cells, and nerve cells. It is also expressed in the liver, which is the main organ that eliminates sulfate from the body. SULF1 is a good candidate for a drug target or biomarker because of its unique structure and function in regulating sulfate levels in the body.

In conclusion, SULF1 is a protein that is involved in the regulation of sulfate levels in the body. It is a key enzyme in the production of tetrathionein and is involved in the regulation of other sulfate-containing molecules. As a result, it is a good candidate for a drug target or biomarker. Further research is needed to fully understand the role of SULF1 in the regulation of sulfate levels in the body and to develop new treatments based on this protein.

Protein Name: Sulfatase 1

Functions: Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity (PubMed:12368295, PubMed:12686563). It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin (PubMed:12368295, PubMed:12686563). Diminishes HSPG (heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation, and facilitates apoptosis in response to exogenous stimulation (PubMed:12686563)

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