Understanding STEAP3: Potential Drug Target Or Biomarker (G55240)

Target Name: STEAP3

NCBI ID: G55240

Understanding STEAP3: Potential Drug Target Or Biomarker

STEAP3, short for STudy of the Extracellular Environment-Protein-Protein Interactions, is a protein that is expressed in various tissues throughout the body. It plays a crucial role in the regulation of cellular processes, including cell signaling, DNA replication, and chromatin structure. The study of STEAP3 has significant implications for our understanding of the complex interplay between proteins, DNA, and cellular processes.

Research has shown that STEAP3 is involved in numerous cellular processes, including the regulation of DNA replication, cell signaling, and chromatin structure. It has been shown to interact with numerous proteins, including TP53, DHF2, and p53. These interactions play a significant role in the regulation of cellular processes, including cell growth, apoptosis, and development.

One of the significant findings related to STEAP3 is its role in the regulation of DNA replication. STEAP3 has been shown to interact with the protein TP53, which is a key regulator of DNA replication. This interaction between STEAP3 and TP53 suggests that STEAP3 may play a role in the regulation of DNA replication.

Another area of research related to STEAP3 is its role in cell signaling. STEAP3 has been shown to interact with the protein p53, which is a well-known regulator of cellular stress. This interaction between STEAP3 and p53 suggests that STEAP3 may play a role in the regulation of cellular stress and stress-induced signaling pathways.

In addition to its role in cell signaling, STEAP3 has also been shown to play a significant role in the regulation of chromatin structure. STEAP3 has been shown to interact with the protein DFAA1, which is a regulator of chromatin structure. This interaction between STEAP3 and DFAA1 suggests that STEAP3 may play a role in the regulation of chromatin structure, including the regulation of gene expression.

The study of STEAP3 also has significant implications for our understanding of the aging process. As we age, the number of cells in the body decreases, and the rate of cellular processes slows down. It is thought that the regulation of STEAP3 by various proteins, including TP53, p53, and DFAA1, may play a role in the regulation of cellular processes as we age.

In conclusion, the study of STEAP3 is significant for our understanding of the complex interplay between proteins, DNA, and cellular processes. Its role in the regulation of DNA replication, cell signaling, and chromatin structure suggests that STEAP3 may be a drug target or biomarker for a variety of diseases. Further research is needed to fully understand the role of STEAP3 in cellular processes and its potential as a drug target or biomarker.

Protein Name: STEAP3 Metalloreductase

Functions: Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Can also reduce of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NADP(+) as acceptor. May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP

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