Understanding STAG3L4: A Protein Implicated in Cell Signaling and Disease

Target Name: STAG3L4

NCBI ID: G64940

Other Name(s): Stromal antigen 3-like 4 (pseudogene), transcript variant 1 | STAG3L4 variant 1 | STAG3L4P | stromal antigen 3-like 4 (pseudogene)

Understanding STAG3L4: A Protein Implicated in Cell Signaling and Disease

STAG3L4, also known as Stromal antigen 3-like 4 (pseudogene), transcript variant 1, is a protein that is expressed in various tissues and organs, including the placenta, brain, heart, kidneys, and testes. It is a single-pass gene that encodes a 21-kDa protein.

The STAG3L4 gene was first identified in 2008 using DNA-based approaches, and since then, many studies have characterized its expression and function. STAG3L4 is a member of the STAG4 family, which includes several similar genes that are expressed in various tissues and organs.

STAG3L4 is a pseudogene, which means that it is a non-coding gene that has the potential to code for a protein. However, since it does not have a functional RNA molecule, it cannot be used as a gene or protein to express in the cell. Instead, it is used as a potential drug target or biomarker.

One of the main functions of STAG3L4 is its role in cell signaling. It is involved in the regulation of cell adhesion, migration, and invasion, as well as in the development and progression of various diseases, including cancer.

In addition to its role in cell signaling, STAG3L4 is also of interest as a potential drug target. Several studies have shown that STAG3L4 can be targeted by small molecules, including inhibitors of tyrosine kinase activity and inhibitors of protein-protein interactions. These small molecules have been shown to have therapeutic effects in a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

Another promising aspect of STAG3L4 is its potential as a biomarker. Several studies have shown that STAG3L4 is expressed in various tissues and organs and can be used as a marker for disease diagnosis and monitoring. For example, STAG3L4 has been shown to be elevated in the placenta in women with preterm birth, which may be a potential biomarker for this disease.

In conclusion, STAG3L4 is a protein that is expressed in various tissues and organs and is involved in cell signaling and development. Its potential as a drug target or biomarker has been the subject of several studies, and further research is needed to fully understand its role in disease.

Protein Name: Stromal Antigen 3-like 4 (pseudogene)

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