ST6GALNAC1 Gene: Key Player in Gut-Brain Barrier and Cancer Development

Target Name: ST6GALNAC1

NCBI ID: G55808

Other Name(s): ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1, transcript variant 1 | ST6GalNAc I | Sialyltransferase 7A | sialyltransferase 7A | ST6GalNAc-I | Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 | ST6GALNAC1, alpha-2,6-sialyltransferase 1 | Sialyltransferase 7 ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase) A | ST6GALNAC1 variant 1 | Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 (isoform 1) | hST6GalNAc-I | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 | sialyltransferase 7 ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase) A | ST6 GalNAc alpha-2,6-sialyltransferase 1 | ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 | HSY11339 | ST6GalNAcI | STYI | SIAT7-A | GalNAc alpha-2,6-sialyltransferase I | galNAc alpha-2,6-sialyltransferase I | GalNAc alpha-2, 6-sialyltransferase I, long form | SIAT7A | SIA7A_HUMAN

ST6GALNAC1 Gene: Key Player in Gut-Brain Barrier and Cancer Development

ST6GALNAC1, also known as ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1, is a gene that encodes a protein located on chromosome 6. This gene is a key player in the development and maintenance of the gut-brain barrier, which is a critical barrier that separates the brain from the rest of the body and plays a crucial role in maintaining the health and function of the nervous system.

The ST6GALNAC1 gene has been associated with a number of different diseases, including autism, neurodegenerative diseases, and gastrointestinal disorders. In addition, the protein encoded by this gene has also been shown to play a role in the development of certain types of cancer.

One of the most promising aspects of the ST6GALNAC1 gene is its potential as a drug target. By targeting the ST6GALNAC1 gene, researchers may be able to develop new treatments for a variety of diseases.

In addition to its potential as a drug target, the ST6GALNAC1 gene has also been shown to be a valuable biomarker for a number of diseases. For example, researchers have used ST6GALNAC1 to diagnose and monitor the effectiveness of treatments for gastrointestinal disorders, such as inflammatory bowel disease and inflammatory bowel disease.

In addition to its use as a drug and biomarker, the ST6GALNAC1 gene also has important implications for our understanding of the gut-brain barrier and the role of this barrier in maintaining the health and function of the nervous system.

The ST6GALNAC1 gene is a key player in the development and maintenance of the gut-brain barrier, which is a critical barrier that separates the brain from the rest of the body and plays a crucial role in maintaining the health and function of the nervous system. This barrier is made up of a variety of different cells, including neurons and glial cells, which are responsible for transmitting and processing signals from the brain to the rest of the body.

In addition to its role in the gut-brain barrier, the ST6GALNAC1 gene has also been shown to play a role in the development of certain types of cancer. For example, studies have shown that individuals with certain genetic variations, including those found in the ST6GALNAC1 gene, are at an increased risk of developing certain types of cancer, such as breast cancer and colon cancer.

In addition to its potential as a drug target and biomarker, the ST6GALNAC1 gene has also been shown to have important implications for our understanding of the gut-brain barrier and the role of this barrier in maintaining the health and function of the nervous system.

The ST6GALNAC1 gene is a key player in the development and maintenance of the gut-brain barrier, which is a critical barrier that separates the brain from the rest of the body and plays a crucial role in maintaining the health and function of the nervous system. This barrier is made up of a variety of different cells, including neurons and glial cells, which are responsible for transmitting and processing signals from the brain to the rest of the body.

In addition to its role in the gut-brain barrier, the ST6GALNAC1 gene has also been shown to play a role in the development of certain types of cancer. For example, studies have shown that individuals with certain genetic variations, including those found in the ST6GALNAC1 gene, are at an increased risk of developing certain types of cancer, such as breast cancer and colon cancer.

In addition to its potential as a drug target and biomarker, the ST6GALNAC1 gene also has important implications for our understanding of the role of this barrier in maintaining the health and function of the nervous system.

Protein Name: ST6 N-acetylgalactosaminide Alpha-2,6-sialyltransferase 1

Functions: Protein sialyltransferase specifically expressed in goblet cells that plays a key role in intestinal host-commensal homeostasis (PubMed:35303419). Conjugates sialic acid with an alpha-2-6 linkage to N-acetylgalactosamine (GalNAc) glycan chains linked to serine or threonine in glycoproteins (PubMed:16319059, PubMed:35303419). Catalyzes the formation of the sialyl-Tn (S-Tn) antigen, an antigen found in intestinal goblet cells, as well as ulcerative colitis (UC) and various cancers (PubMed:16319059, PubMed:35303419). Protein sialylation in globlet cells is essential for mucus integrity and is required to protect the intestinal mucus against excessive bacterial proteolytic degradation (PubMed:35303419)

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