SSH1: A Drug Target / Disease Biomarker (G54434)

Target Name: SSH1

NCBI ID: G54434

SSH1: A Drug Target / Disease Biomarker

SSH1 (Securin) is a protein that is expressed in various tissues throughout the body, including the brain, heart, liver, and kidney. It is a member of the superfamily of cytoplasmic user proteins (SUP), which are involved in various cellular processes, including cytoskeletal organization, cell signaling, and intracellular transport. SSH1 is characterized by a unique N-terminus that consists of a catalytic domain, a transmembrane region, and a C-terminus that is involved in protein-protein interactions.

SSH1 has been identified as a potential drug target due to its involvement in various cellular processes that are relevant to several diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Its unique structure and function have also made it a promising biomarker for the diagnosis and treatment of these diseases.

One of the key functions of SSH1 is its role in intracellular signaling. It is involved in the regulation of various cellular processes, including cell adhesion, migration, and survival. SSH1 has been shown to play a critical role in the regulation of neural cell migration, and its expression has been implicated in the development of neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease.

In addition to its role in intracellular signaling, SSH1 is also involved in the regulation of cytoskeletal organization. It is a key component of the microtubules, which are the organizing structures that make up the cytoskeleton. The cytoskeleton is responsible for maintaining the shape and integrity of the cell, and it plays a critical role in cell signaling and intracellular transport.

The unique structure of SSH1 has also made it a potential drug target. Its catalytic domain is involved in the regulation of various cellular processes, and drugs that can interact with this domain have been shown to have a range of therapeutic effects, including the treatment of cancer, neurodegenerative diseases, and autoimmune disorders.

In conclusion, SSH1 is a protein that is expressed in various tissues throughout the body and is involved in various cellular processes that are relevant to several diseases. Its unique structure and function have also made it a potential drug target, with potential therapeutic effects in the treatment of cancer, neurodegenerative diseases, and autoimmune disorders. Further research is needed to fully understand the role of SSH1 in these diseases and to develop effective treatments.

Protein Name: Slingshot Protein Phosphatase 1

Functions: Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein

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