Understanding SRP68: A Potential Drug Target and Biomarker (G6730)
Understanding SRP68: A Potential Drug Target and Biomarker
SRP68 (SRP68_HUMAN) is a protein that is expressed in various tissues of the human body. It is a scaffold protein that plays a critical role in the structure and function of various cell types. SRP68 is a potential drug target and has been identified as a potential biomarker for various diseases, including cancer.
The protein SRP68 is composed of 155 amino acid residues and has a calculated molecular weight of 19.1 kDa. It is expressed in various tissues of the human body, including the liver, spleen, kidney, and heart. SRP68 is also expressed in the placenta and has been shown to be involved in the development and maintenance of blood vessels.
One of the unique features of SRP68 is its ability to interact with other proteins. It has been shown to interact with a variety of proteins, including the transcription factor NF-kappa-B and the protein T-cell factor (TGF-β). These interactions play a critical role in the regulation of various cellular processes, including cell growth, differentiation, and inflammation.
SRP68 has also been shown to be involved in the regulation of cellular processes that are important for the development and progression of cancer. For example, studies have shown that high levels of SRP68 are associated with the development of cancer. Additionally, SRP68 has been shown to play a critical role in the regulation of the angiogenesis, which is the process by which new blood vessels are formed.
In addition to its role in the regulation of cellular processes, SRP68 has also been shown to be involved in the regulation of cellular interactions. For example, studies have shown that SRP68 interacts with the protein PDGF-BB, which is a key regulator of cellular interactions. These interactions play a critical role in the regulation of cellular processes, including cell growth, differentiation, and survival.
SRP68 has also been shown to be involved in the regulation of the immune response. For example, studies have shown that SRP68 interacts with the protein PD-L1, which is a critical regulator of the immune response. These interactions play a critical role in the regulation of cellular processes, including immune surveillance and immune tolerance.
In conclusion, SRP68 is a protein that is expressed in various tissues of the human body and has been shown to play a critical role in the regulation of various cellular processes. Its unique ability to interact with other proteins and its involvement in the regulation of cellular processes that are important for the development and progression of cancer, angiogenesis, and the immune response make it an attractive potential drug target and biomarker. Further research is needed to fully understand the role of SRP68 in the regulation of cellular processes and its potential as a drug target and biomarker.
Protein Name: Signal Recognition Particle 68
Functions: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:34020957). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER (PubMed:34020957). The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER (PubMed:34020957). Binds the signal recognition particle RNA (7SL RNA), SRP72 binds to this complex subsequently (PubMed:16672232, PubMed:27899666). The SRP complex possibly participates in the elongation arrest function (By similarity)
More Common Targets
SRP72 | SRP9 | SRP9P1 | SRPK1 | SRPK2 | SRPK3 | SRPRA | SRPRB | SRPX | SRPX2 | SRR | SRRD | SRRM1 | SRRM1P1 | SRRM2 | SRRM2-AS1 | SRRM3 | SRRM4 | SRRM5 | SRRT | SRSF1 | SRSF10 | SRSF11 | SRSF12 | SRSF2 | SRSF3 | SRSF3P2 | SRSF4 | SRSF5 | SRSF6 | SRSF6P1 | SRSF7 | SRSF8 | SRSF9 | SRXN1 | SRY | SS18 | SS18L1 | SS18L2 | SSB | SSBP1 | SSBP2 | SSBP3 | SSBP3-AS1 | SSBP3P2 | SSBP4 | SSC4D | SSC5D | SSH1 | SSH2 | SSH3 | SSMEM1 | SSNA1 | SSPN | SSPOP | SSR1 | SSR1P2 | SSR2 | SSR3 | SSR4 | SSR4P1 | SSRP1 | SST | SSTR1 | SSTR2 | SSTR3 | SSTR4 | SSTR5 | SSTR5-AS1 | SSU72 | SSU72L2 | SSU72P1 | SSU72P8 | SSUH2 | SSX1 | SSX2 | SSX2IP | SSX3 | SSX4 | SSX5 | SSX6P | SSX7 | SSX8P | SSX9P | SSXP10 | SSXP5 | ST13 | ST13P16 | ST13P18 | ST13P20 | ST13P4 | ST13P5 | ST14 | ST18 | ST20 | ST20-AS1 | ST20-MTHFS | ST3GAL1 | ST3GAL2 | ST3GAL3