SRSF2: A Potential Drug Target and Biomarker (G6427)

Target Name: SRSF2

NCBI ID: G6427

SRSF2: A Potential Drug Target and Biomarker

S RSF2 (Protein PR264) is a heat shock protein (HSP) that is expressed in various tissues and cells throughout the body. It plays a crucial role in the regulation of cellular stress responses, and its levels have been shown to be affected by a variety of factors, including stress, exercise, and disease.

SRSF2 has been identified as a potential drug target due to its unique structure and its ability to interact with a variety of molecules. The protein has four known isoforms, which are different in their size and localization within the cell. SRSF2 has been shown to interact with a variety of protein partners, including casein, alpha-actinin, and myosin.

One of the most promising aspects of SRSF2 is its ability to modulate the activity of other proteins. Studies have shown that SRSF2 can interact with and inhibit the activity of the protein heat shock factor (HSP70), which is a protein that is involved in the regulation of cellular stress responses. This suggests that SRSF2 may be a useful drug target for diseases that are characterized by chronic stress, such as neurodegenerative diseases, cancer, and chronic obstructive pulmonary disease (COPD).

In addition to its potential as a drug target, SRSF2 has also been shown to be a potential biomarker for a variety of diseases. The levels of SRSF2 have been shown to be affected by a variety of factors, including stress, exercise, and disease. For example, studies have shown that SRSF2 levels are elevated in individuals with heart disease, and that they are decreased in individuals with cancer. These findings suggest that SRSF2 may be a useful biomarker for these diseases, and that it may be a potential target for new therapies.

SRSF2 has also been shown to play a role in the regulation of cellular processes that are important for human health. For example, studies have shown that SRSF2 is involved in the regulation of cell division, and that it plays a role in the development of cancer. In addition, SRSF2 has been shown to be involved in the regulation of inflammation, and that it may play a role in the development of autoimmune diseases.

In conclusion, SRSF2 is a protein that has the potential to be a drug target and a biomarker for a variety of diseases. Its unique structure and its ability to interact with a variety of molecules make it an attractive target for new therapies. Further research is needed to fully understand the role of SRSF2 in cellular processes and its potential as a drug and biomarker.

Protein Name: Serine And Arginine Rich Splicing Factor 2

Functions: Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5'-GTTCGAGTA-3'. Can bind to beta-globin mRNA and commit it to the splicing pathway. The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment

More Common Targets