SPRED3: A Potential Drug Target and Biomarker (G399473)

Target Name: SPRED3

NCBI ID: G399473

SPRED3: A Potential Drug Target and Biomarker

Sprouty-related, EVH1 domain-containing protein 3 (SPRED3) is a protein that has been identified as a potential drug target and biomarker. Its unique structure and function have made it an attractive target for researchers to study.

SPRED3 is a protein that is expressed in various tissues, including the brain, heart, and kidneys. It is made up of 211 amino acids and has a calculated molecular mass of 21.1 kDa. SPRED3 is localized to the endoplasmic reticulum (ER) and is predominantly expressed in the proteinosome, a complex that retrieves and processes misfolded proteins.

One of the unique features of SPRED3 is its ability to interact with other proteins, including the proteinase 2 (P2) protein. P2 is a key regulator of protein degradation and has been shown to interact with various protein substrates, including SPRED3. This interaction between P2 and SPRED3 suggests that SPRED3 may be a useful drug target for the treatment of protein-related diseases.

In addition to its potential as a drug target, SPRED3 has also been identified as a potential biomarker for a variety of diseases. Its expression has been shown to be elevated in a variety of diseases, including neurodegenerative disorders, cancer, and cardiovascular disease. This suggests that SPRED3 may be a useful biomarker for the diagnosis and monitoring of these diseases.

SPRED3's unique structure and function also make it an attractive target for drug development. Its small size and localization to the ER make it a potential candidate for small molecule inhibitors. Additionally, its interaction with P2 suggests that it may be a useful target for drugs that target the regulation of protein degradation.

In conclusion, SPRED3 is a protein with great potential as a drug target and biomarker. Its unique structure and function make it an attractive target for the development of new therapies for a variety of diseases. Further research is needed to fully understand its potential and to develop safe and effective drugs that target SPRED3.

Protein Name: Sprouty Related EVH1 Domain Containing 3

Functions: Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase (By similarity). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity)

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