SPI1: Key Regulator of Cell Growth and Differentiation (G6688)

Target Name: SPI1

NCBI ID: G6688

SPI1: Key Regulator of Cell Growth and Differentiation

SPI1 (31 kDa transforming protein) is a protein that is expressed in a wide range of tissues and cells in the human body. It is a key regulator of cell growth and differentiation, and is involved in the development and maintenance of tissues such as muscles , bones, and skin.

SPI1 is a member of the transforming protein family, which includes a group of proteins that play a critical role in the regulation of cell growth and differentiation. These proteins are characterized by the presence of a unique transmembrane domain, which is involved in the formation of a complex with various cytoplasmic proteins.

One of the key functions of SPI1 is its role in the regulation of cell proliferation. SPI1 has been shown to play a positive role in the growth and development of various tissues, including muscles, bones, and skin. It is also involved in the regulation of cell cycle progression, which is the process by which cells grow and divide.

In addition to its role in cell proliferation, SPI1 is also involved in the regulation of cell differentiation. It has been shown to play a critical role in the development and maintenance of various tissues, including the nervous system and the endocrine system.

SPI1 is also involved in the regulation of cellular signaling pathways. It is a negative regulator of the TGF-β pathway, which is a well-known regulator of cell growth and differentiation. TGF-β is involved in the development and maintenance of tissues such as muscles, bones, and skin, and is activated by SPI1.

SPI1 is also involved in the regulation of cytoskeletal organization. It plays a critical role in the organization of actin filaments, which are involved in the regulation of cell shape and movement.

In conclusion, SPI1 is a protein that is involved in a wide range of cellular processes in the human body. It is a key regulator of cell growth and differentiation, and is involved in the development and maintenance of tissues such as muscles, bones, and skin. Its role in these processes makes it an attractive drug target, and SPI1 may be a useful biomarker for the diagnosis and treatment of various diseases.

Protein Name: Spi-1 Proto-oncogene

Functions: Pioneer transcription factor, which controls hematopoietic cell fate by decompacting stem cell heterochromatin and allowing other transcription factors to enter otherwise inaccessible genomic sites. Once in open chromatin, can directly control gene expression by binding genetic regulatory elements and can also more broadly influence transcription by recruiting transcription factors, such as interferon regulatory factors (IRFs), to otherwise inaccessible genomic regions (PubMed:23658224, PubMed:33951726). Transcriptionally activates genes important for myeloid and lymphoid lineages, such as CSF1R (By similarity). Transcriptional activation from certain promoters, possibly containing low affinity binding sites, is achieved cooperatively with other transcription factors. FCER1A transactivation is achieved in cooperation with GATA1 (By similarity). May be particularly important for the pro- to pre-B cell transition (PubMed:33951726). Binds (via the ETS domain) onto the purine-rich DNA core sequence 5'-GAGGAA-3', also known as the PU-box (PubMed:33951726). In vitro can bind RNA and interfere with pre-mRNA splicing (By similarity)

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