SPDEF: A Sam-related Protein with Ets-like Domain Regulates Stem Cell Proliferation and Differentiation

Target Name: SPDEF

NCBI ID: G25803

SPDEF: A Sam-related Protein with Ets-like Domain Regulates Stem Cell Proliferation and Differentiation

SPDEF, or Sam-related protein with Ets-like domain, is a protein that is expressed in various tissues and organs in the body. It is a transcription factor that plays a crucial role in the regulation of gene expression. SPDEF is a key regulator of stem cell proliferation and differentiation, and it has been implicated in a number of diseases, including cancer, neurodegenerative diseases, and developmental disorders.

SPDEF is a protein that is characterized by an N-terminal region that contains a conserved nucleotide sequence known as the "sp pool" (SPD), which is also found in other transcription factors, such as SAMD2 and SAFR. The SPD is a critical region for SPDEF function, as it allows the protein to interact with DNA and regulate gene expression.

SPDEF is a domain-containing protein that is composed of multiple functional domains, including an N-terminal alpha-helix, a beta-sheet, and a C-terminal T-loop. The N-terminal region of SPDEF contains a conserved nucleotide sequence that is known as the "sp pool" (SPD). This region is critical for the function of the protein, as it allows SPDEF to interact with DNA and regulate gene expression.

SPDEF is a transcription factor that has been shown to play a role in the regulation of stem cell proliferation and differentiation. It has been shown to promote the self-renewal and maintenance of stem cells, and it has been implicated in the development of cancer.

SPDEF has also been shown to play a role in the regulation of neural development and behavior. It has been shown to be involved in the regulation of neuronal differentiation and the development of neural circuits, and it has been implicated in the development of neurodegenerative diseases.

SPDEF has also been shown to play a role in the regulation of immune system and metabolic rate. It has been shown to be involved in the regulation of immune cell function and metabolism, and it has been implicated in the development of autoimmune diseases and obesity.

In conclusion, SPDEF is a protein that is characterized by an N-terminal region that contains a conserved nucleotide sequence known as the "sp pool" (SPD). This region is critical for the function of the protein, as it allows SPDEF to interact with DNA and regulate gene expression. SPDEF is a transcription factor that has been shown to play a role in the regulation of stem cell proliferation and differentiation, neural development and behavior, and immune system and metabolism. As such, SPDEF may be a drug target or biomarker for a variety of diseases.

Protein Name: SAM Pointed Domain Containing ETS Transcription Factor

Functions: May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5'-GGAT-3' DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer development. Acts as a transcriptional activator for SERPINB5 promoter

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