SPHK2 Gene Linked To Various Neurological Diseases (G56848)

Target Name: SPHK2

NCBI ID: G56848

SPHK2 Gene Linked To Various Neurological Diseases

SPHK2 (SPHEN2) is a gene that has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative disorders, and autoimmune diseases. The gene is located on chromosome 16 and encodes a protein known as SPHK2, which is involved in the development and maintenance of the blood-brain barrier.

The blood-brain barrier is a specialized barrier that separates the brain from the surrounding bloodstream, and it is critical for the protection of the brain and the regulation of its function. However, abnormal angiogenesis and neuronal death may lead to tumors and neurological disease. The occurrence of degenerative diseases. Therefore, studying the role of SPHK2 in the treatment of these diseases has important clinical significance.

Variations in the SPHK2 gene have been shown to be associated with a variety of neurological diseases. For example, variations in the SPHK2 gene are associated with increased incidence of Parkinson's disease, a neurodegenerative disorder characterized by muscle stiffness and decreased movement. Additionally, variations in the SPHK2 gene are associated with cognitive decline in patients with Alzheimer's disease and Parkinson's disease.

In addition, the SPHK2 gene is also closely related to the occurrence and development of cancer. For example, variations in the SPHK2 gene have been shown to be associated with an increased incidence of various cancers, including lung, liver, and breast cancer. Therefore, studying the role of SPHK2 in cancer treatment also has important clinical significance.

The SPHK2 protein also plays an important role in maintaining the blood-brain barrier. Research shows that SPHK2 protein can inhibit the activity of vascular endothelial growth factor (VEGF), a key molecule that promotes angiogenesis. By inhibiting VEGF activity, SPHK2 can reduce angiogenesis, thereby reducing the risk of tumors and neurodegenerative diseases.

In addition, SPHK2 protein can also regulate neuronal survival and apoptosis. Research shows that SPHK2 protein can inhibit neuronal apoptosis, thereby

Protein Name: Sphingosine Kinase 2

Functions: Catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-dihydrosphingosine, D-erythro-sphingosine and L-threo-dihydrosphingosine. Binds phosphoinositides (PubMed:19168031, PubMed:12954646). In contrast to prosurvival SPHK1, has a positive effect on intracellular ceramide levels, inhibits cells growth and enhances apoptosis (PubMed:16118219). In mitochondria, is important for cytochrome-c oxidase assembly and mitochondrial respiration. The SPP produced in mitochondria binds PHB2 and modulates the regulation via PHB2 of complex IV assembly and respiration (PubMed:20959514). In nucleus, plays a role in epigenetic regulation of gene expression. Interacts with HDAC1 and HDAC2 and, through SPP production, inhibits their enzymatic activity, preventing the removal of acetyl groups from lysine residues with histones. Up-regulates acetylation of histone H3-K9, histone H4-K5 and histone H2B-K12 (PubMed:19729656). In nucleus, may have an inhibitory effect on DNA synthesis and cell cycle (PubMed:12954646, PubMed:16103110). In mast cells, is the main regulator of SPP production which mediates calcium influx, NF-kappa-B activation, cytokine production, such as TNF and IL6, and degranulation of mast cells (By similarity). In dopaminergic neurons, is involved in promoting mitochondrial functions regulating ATP and ROS levels (By similarity). Also involved in the regulation of glucose and lipid metabolism (By similarity)

More Common Targets