SPC24: A Protein Essential for Mitochondrial Cell Survival (G147841)

Target Name: SPC24

NCBI ID: G147841

SPC24: A Protein Essential for Mitochondrial Cell Survival

SPC24 is a protein that is found in the spindle pole body (SPB) of the human mitochondria. The SPB is a complex structure that is responsible for the maintenance of the mitochondrial cytoskeleton and is involved in various cellular processes that are essential for cell survival. SPC24 is one of the key components of the SPB and is essential for its proper function.

SPC24 is a protein that consists of 24 amino acid residues. It has a molecular weight of 30 kDa and a pre-clearance value of 11 kDa. SPC24 is predominantly localized to the cytoplasm of the SPB and is also found in the mitochondrial inner mitochondrial membrane and the outer mitochondrial membrane.

SPC24 plays a crucial role in the maintenance of the integrity of the SPB. It is involved in the formation of the SPB and helps to ensure that it remains stable and cytoplasmic. SPC24 is also involved in the regulation of the SPB's dynamics and in the assembly and disassembly of the SPB.

SPC24 is a protein that is often used as a drug target or biomarker. For example, SPC24 has been used as a drug target for various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. Researchers have been interested in SPC24 because of its potential as a drug target due to its unique structure and its involvement in important cellular processes.

In addition to its potential as a drug target, SPC24 has also been shown to be a useful biomarker for various diseases. For example, SPC24 has been used as a biomarker for cancer, neurodegenerative diseases, and autoimmune diseases. Researchers have been interested in using SPC24 as a biomarker because of its stability and its ability to be used in a variety of experimental conditions.

SPC24 is a protein that is found in the SPB of the human mitochondria. It is a key component of the SPB and is involved in various cellular processes that are essential for cell survival. SPC24 has been shown to be a potential drug target and a useful biomarker for various diseases.

Protein Name: SPC24 Component Of NDC80 Kinetochore Complex

Functions: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:14738735). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:14738735). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020)

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