SPATA5L1: A Non-Coding RNA Molecule Regulating RPNI Function and Cancer Development

Target Name: SPATA5L1

NCBI ID: G79029

SPATA5L1: A Non-Coding RNA Molecule Regulating RPNI Function and Cancer Development

SPATA5L1 (Splice Enhancer-containing transcription factor 5 gene 1) is a non-coding RNA molecule that plays a critical role in the regulation of gene expression in various organisms, including humans. It is a key regulator of the RNA polymerase II (RPNI) complex, which is responsible for transcribing DNA into RNA. RPNI is a protein that consists of multiple subunits that interact with specific DNA sequences to ensure the accuracy and efficiency of RNA synthesis.

SPATA5L1 is a 21-kDa RNA molecule that contains 19 exons and 2 intron. It is expressed in various tissues and cells of the human body, including the brain, heart, and liver. It is also highly expressed in the placenta, which is a critical organ that supports the development and growth of new fetuses.

SPATA5L1 is a key regulator of RPNI function. It interacts with the RPNI subunit alpha 2 (RNA polymerase II subunit alpha 2) to enhance its activity. This interaction between SPATA5L1 and alpha 2 is critical for the efficient transcription of RNA into protein.

SPATA5L1 is also involved in the regulation of gene expression in cancer cells. It has been shown to play a role in the development and progression of various types of cancer, including neurobladder cancer, colorectal cancer, and breast cancer.

SPATA5L1 is a potential drug target for cancer treatment. Because of its role in cancer, studying SPATA5L1 as a drug target or biomarker may help in the treatment of cancer.

In addition, SPATA5L1 can serve as an important tool for studying gene expression and regulation. Scientists can use RNA sequencing technology to study the role of SPATA5L1 in gene expression and regulation. They can also use RNA interference technology with SPATA5L1 to study the effects of SPATA5L1 on gene expression.

In summary, SPATA5L1 is a critical regulator of gene expression that plays a role in the development and progression of various types of cancer. It is a potential drug target for cancer treatment, and researchers are currently studying its role in gene expression and regulation.

Protein Name: Spermatogenesis Associated 5 Like 1

Functions: ATP-dependent chaperone, which plays an essential role in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre-ribosomal particles (PubMed:35354024). Acts together with SPATA5, C1orf109 and CINP (PubMed:35354024)

More Common Targets