SPATA24: Regulator of The Cell Cycle and Potential Drug Target

Target Name: SPATA24

NCBI ID: G202051

SPATA24: Regulator of The Cell Cycle and Potential Drug Target

SPATA24, also known as coiled-coil domain containing 161, is a protein that is expressed in various tissues of the body, including the brain, heart, and liver. It is a key regulator of the cell cycle, and its dysfunction has been implicated in a number of diseases, including cancer, neurodegenerative diseases, and developmental disorders.

SPATA24 is a protein that is made up of a unique structure known as a coiled-coil domain. This domain is composed of a series of amino acids that are repeated in a specific order, forming a positively charged region that is capable of interacting with other proteins. The coiled-coil domain is the primary mechanism that SPATA24 functions as a regulator of the cell cycle.

SPATA24 plays a critical role in the regulation of the cell cycle at different stages. During the G1 phase, SPATA24 is involved in the accumulation of mobile genetic elements, which are important for the transfer of genetic information during cell division. During the S phase, SPATA24 is involved in the maintenance of genomic stability by preventing the inversion of the DNA double helix that can occur during cell division.

SPATA24 is also involved in the regulation of the cell cycle during the G2 and M phases. During G2, SPATA24 is involved in the progression of cells through the checkpoint response, which is a critical step in the cell cycle that ensures that the cell is ready for cell division. During M phase, SPATA24 is involved in the metaphase, which is the stage of cell division where the chromosomes are replicated and the cell divides.

SPATA24 has also been shown to play a role in a number of diseases, including cancer. For example, studies have shown that SPATA24 is often overexpressed in various types of cancer, including breast, ovarian, and prostate cancer. This increase in SPATA24 expression has been shown to contribute to the development and progression of these diseases.

In addition to its role in the cell cycle, SPATA24 has also been shown to play a role in a number of other processes that are important for the health and function of the body. For example, SPATA24 has been shown to be involved in the regulation of cell adhesion, which is the process by which cells stick together and form tissues. SPATA24 has also been shown to be involved in the regulation of the cytoskeleton, which is the structure that gives cells shape and stability.

SPATA24 has also been shown to play a role in a number of other processes that are important for the health and function of the body. For example, SPATA24 has been shown to be involved in the regulation of cell signaling, which is the process by which cells communicate with one another to carry out various tasks. SPATA24 has also been shown to be involved in the regulation of inflammation, which is a critical immune response that helps protect the body against infection and disease.

In conclusion, SPATA24 is a protein that is involved in a number of important processes that help regulate the cell cycle and contribute to the health and function of the body. Its dysfunction has been implicated in a number of diseases, including cancer, neurodegenerative diseases, and developmental disorders. As such, SPATA24 is a potential drug target and a biomarker for a variety of diseases. Further research is needed to fully understand the role of SPATA24 in these processes and to develop effective treatments.

Protein Name: Spermatogenesis Associated 24

Functions: Binds DNA with high affinity but does not bind to TATA boxes. Synergises with GMNN and TBP in activation of TATA box-containing promoters and with GMNN and TBPL1 in activation of the NF1 TATA-less promoter. May play a role in cytoplasm movement and removal during spermiogenesis (By similarity)

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