SPATA2: A Potential Drug Target for Male Fertility and Sexual Behavior

Target Name: SPATA2

NCBI ID: G9825

SPATA2: A Potential Drug Target for Male Fertility and Sexual Behavior

SPATA2 (Sperm-associated protein 2) is a protein that is expressed in high levels in the testes and other organs of male mice. It is a key regulator of sperm development and plays a crucial role in the formation of normal spermatozoa.

Recent studies have identified SPATA2 as a potential drug target for the treatment of infertility and other male-related conditions. This is because SPATA2 has been shown to be involved in a number of important processes that are involved in male fertility, including the development and function of sperm, as well as the regulation of sexual behavior.

One of the key functions of SPATA2 is its role in the development of spermatozoa. SPATA2 is involved in the formation of the mitochondria that are responsible for providing energy to the developing spermatozoa. This is important for the survival and fertility of the spermatozoa.

In addition to its role in sperm development, SPATA2 is also involved in the regulation of sexual behavior. Studies have shown that SPATA2 is involved in the development and maintenance of sexual behavior in male mice, including mating and orgasm.

SPATA2 has also been shown to be involved in the regulation of other processes that are important for male fertility, including the development and function of the testes, as well as the production of hormones that are involved in male reproductive biology.

Given the important role that SPATA2 plays in male fertility and sexual behavior, it is a promising target for the development of new treatments for infertility and other male-related conditions. Researchers are currently working to develop new drugs that can inhibit the activity of SPATA2 in order to improve fertility and sexual behavior in male mice.

While more research is needed to fully understand the role of SPATA2 in male fertility and sexual behavior, it is clear that this protein is an important target for the development of new treatments for infertility and other male-related conditions.

Protein Name: Spermatogenesis Associated 2

Functions: Bridging factor that mediates the recruitment of CYLD to the LUBAC complex, thereby regulating TNF-alpha-induced necroptosis (PubMed:27307491, PubMed:27458237, PubMed:27545878, PubMed:27591049). Acts as a direct binding intermediate that bridges RNF31/HOIP, the catalytic subunit of the LUBAC complex, and the deubiquitinase (CYLD), thereby recruiting CYLD to the TNF-R1 signaling complex (TNF-RSC) (PubMed:27458237, PubMed:27545878, PubMed:27591049). Required to activate the 'Met-1'- (linear) and 'Lys-63'-linked deubiquitinase activities of CYLD (PubMed:27458237, PubMed:27591049). Controls the kinase activity of RIPK1 and TNF-alpha-induced necroptosis by promoting 'Met-1'-linked deubiquitination of RIPK1 by CYLD (By similarity)

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