GLO1: Key Enzyme in Glutathione Pathway (G2739)

Target Name: GLO1

NCBI ID: G2739

GLO1: Key Enzyme in Glutathione Pathway

GLO1 (Lactoyl glutathione lyase) is a protein that is expressed in various tissues throughout the body, including the liver, spleen, and kidney. It is a key enzyme in the Glutathione pathway, which is a process that helps to eliminate toxins and other harmful substances from the body. GLO1 plays a crucial role in this process by breaking down a protein called GLUT1, which is also known as GLUT-180.

In recent years, GLO1 has gained significant attention as a potential drug target or biomarker due to its involvement in a number of important biological processes. For example, GLO1 has been shown to be involved in the regulation of inflammation, immune response, and cellular stress. It has also been shown to play a role in the development and progression of a number of diseases, including cancer.

One of the key advantages of GLO1 as a drug target is its relatively simple structure. Unlike many other proteins, GLO1 has only four known active sites, which makes it relatively easy to target with small molecules. This has led to a significant number of studies focused on GLO1 as a potential drug, with many researchers exploring the potential effects of various small molecules on GLO1 activity.

GLO1 has also been shown to be involved in the regulation of cellular stress, which is a critical process that helps to maintain the health and stability of cells. When cells are exposed to stressors, such as toxins or radiation, GLO1 helps to regulate the signaling pathways that are activated to help the cell respond to the stress. This helps to ensure that the cell is able to recover from the stress and continue to function properly.

GLO1 has also been shown to play a role in the regulation of inflammation. When the body is exposed to an infection or injury, GLO1 helps to regulate the production of white blood cells, which are important for fighting off the infection or injury. This is important because an imbalance in the levels of white blood cells can lead to chronic inflammation, which can contribute to a number of diseases.

In addition to its role in inflammation and stress response, GLO1 has also been shown to be involved in the regulation of cellular processes that are important for maintaining the structure and function of cells. For example, GLO1 has been shown to help regulate the levels of protein synthesis in cells, which is important for maintaining the integrity of the cell's structure and function.

Despite its potential as a drug target, GLO1 has not yet been widely studied, and there is much that is not yet known about its role in biology. However, the potential involvement of GLO1 in a number of important biological processes makes it an intriguing target for future research. As research continues to advance, it is likely that GLO1 will emerge as a key player in the study of cellular processes and the regulation of important biological processes.

Protein Name: Glyoxalase I

Functions: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione (PubMed:20454679, PubMed:9705294, PubMed:23122816). Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B (PubMed:19199007). Required for normal osteoclastogenesis (By similarity)

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