TRBV14: A Potential Drug Target and Biomarker for T Cell Receptor尾 Variable 14 in Cancer

Target Name: TRBV14

NCBI ID: G28573

Other Name(s): T cell receptor beta variable 14 | TCRBV14S1 | TCRBV16S1A1N1

TRBV14: A Potential Drug Target and Biomarker for T Cell Receptor尾 Variable 14 in Cancer

Abstract:

T cell receptor (TCR)尾 variable 14 (TRBV14) is a non-functional T cell receptor that has been identified as a potential drug target and biomarker in cancer. TRBV14 is a 14-kDa transmembrane protein that is expressed in various tissues, including the brain, spleen, and lymph nodes. It plays a critical role in T cell development, function, and regulation. In this article, we will discuss the TRBV14 protein, its functions, its potential as a drug target, and its potential as a biomarker for cancer.

Introduction:

T cells are a crucial immune system cell that play a critical role in fighting against infections and cancer. T cells are characterized by their ability to recognize and respond to antigens via their TCR, which consists of a variable region that can recognize specific antigens. One of the non-functional TCRs is TRBV14, which is expressed in various tissues and plays a critical role in T cell development, function, and regulation.

TRBV14 is a 14-kDa transmembrane protein that is expressed in various tissues, including the brain, spleen, and lymph nodes. It is a key regulator of T cell receptor (TCR) function, and it has been shown to play a critical role in T cell development, activation, and proliferation. TRBV14 is composed of a variable region, a constant region, and an amino-terminal region. The variable region is the most variable region of the TCR and is responsible for recognizing antigens.

TRBV14 functions:

TRBV14 is involved in T cell receptor (TCR) function by regulating the interactions between the TCR and its cognate antigens. It does this by modulating the activity of several intracellular signaling pathways, including the tyrosine kinase signaling pathway, the PI3K/Akt signaling pathway, and the NF-kappa-B signaling pathway.

TRBV14 has been shown to play a critical role in T cell receptor (TCR) signaling by regulating the interaction between the TCR and its cognate antigens. It has been shown to enhance the sensitivity of T cells to antigens and to improve their ability to recognize and respond to antigens.

TRBV14 has also been shown to play a critical role in T cell cell survival by regulating the activities of several cell signaling pathways, including the T cell signaling pathway, the cell cycle pathway, and the apoptosis pathway.

TRBV14 is a potential drug target:

TRBV14 has been identified as a potential drug target due to its critical role in T cell function and development. Because it plays a vital role in regulating T cell receptor (TCR) function and in modulating the interactions between the TCR and its cognate antigens, it may be a useful target for cancer therapies.

TRBV14 has also been shown to have anti-cancer properties by inhibiting the activities of cell signaling pathways that promote cancer cell growth and survival.

TRBV14 is a potential biomarker for cancer:

TRBV14 has been shown to be expressed in various types of cancer, including breast, lung, and ovarian cancer. It has also been shown to be associated with poor prognosis in patients with these cancers.

TRBV14 has been shown to be a potential biomarker for cancer by its expression and its association with cancer outcomes. It has been shown to be associated with the

Protein Name: T Cell Receptor Beta Variable 14

Functions: V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585)

More Common Targets