TRBV4-3: A Potential Drug Target for Cancer (G28615)

Target Name: TRBV4-3

NCBI ID: G28615

Other Name(s): T cell receptor beta variable 4-3 | TCRBV7S2A1N4T | TRBV43 | TCRBV4S3

TRBV4-3: A Potential Drug Target for Cancer

TRBV4-3 (T cell receptor beta variable 4-3) is a protein that is expressed in T cells, a type of white blood cell that plays a crucial role in the immune system. T cells are responsible for detecting and responding to foreign substances in the body, and they are an important part of the immune system because they help to protect the body against infection and disease.

One of the functions of T cells is to recognize and respond to specific antigens. These antigens can be things like viruses, bacteria, or other microorganisms that are trying to enter the body. When a T cell recognizes an antigen, it becomes activated and begins to divide and differentiate into a specialized type of cell. This process is important because it helps to ensure that the immune system is able to respond quickly and effectively to any threats that may be lurking in the body.

One of the proteins that is involved in this process is TRBV4-3. This protein is a type of receptor that is found on the surface of T cells. It is called a \"T cell receptor\" because it is a protein that is used by T cells to communicate with other T cells and with other cells in the body.

TRBV4-3 is a type of protein that is made up of several different subunits. These subunits work together to help the T cell recognize and respond to specific antigens. Because it is a protein that is expressed in T cells, TRBV4-3 is thought to be an important part of the immune system.

One of the things that makes TRBV4-3 an interesting potential drug target is that it is a protein that is expressed in high levels in many different types of cancer. This means that if an effective way to inhibit TRBV4-3 could be developed, it could potentially be used as a treatment for a variety of different types of cancer.

Another potential benefit of TRBV4-3 as a drug target is that it is a protein that is involved in many different processes in the body. This means that if an effective way to target TRBV4-3 could be developed, it could potentially have a wide range of potential applications in medicine.

In conclusion, TRBV4-3 is a protein that is expressed in T cells and is involved in the process of recognizing and responding to specific antigens. It is also a potential drug target because it is a protein that is expressed in high levels in many different types of cancer and is involved in many different processes in the body. Further research is needed to understand more about the role of TRBV4-3 in the immune system and its potential as a drug.

Protein Name: T Cell Receptor Beta Variable 4-3

Functions: V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585)

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