HTR1E: A G Protein-coupled Receptor Involved in Pain, Anxiety and Sleep

Target Name: HTR1E

NCBI ID: G3354

HTR1E: A G Protein-coupled Receptor Involved in Pain, Anxiety and Sleep

HTR1E, also known as 5-hydroxytryptamine (serotonin) receptor 1E, is a G protein-coupled receptor that is expressed in various tissues throughout the body. It is a member of the G protein-coupled receptor family, which is a large family of transmembrane proteins that play an important role in cellular signaling. HTR1E is one of the many G protein-coupled receptors that are involved in the regulation of physiological processes such as mood, appetite, and sleep.

HTR1E is a TrkB subtype, which means that it belongs to a specific subfamily of G protein-coupled receptors. TrkB subtypes are involved in the regulation of neural circuits, including the modulation of pain, anxiety, and affective states. HTR1E is specifically involved in the regulation of pain and anxiety, and is thought to play a key role in the development of chronic pain.

HTR1E is a potent receptor for the neurotransmitter serotonin, which is a well-known neurotransmitter that is involved in a variety of physiological processes, including mood regulation, appetite, and sleep. Serotonin regulates the activity of various neural circuits, including those involved in pain modulation. It is thought that HTR1E is involved in the regulation of serotonin release and uptake, and that it plays a key role in the development of chronic pain.

In addition to its role in pain and anxiety regulation, HTR1E is also involved in the regulation of other physiological processes. For example, it is thought to be involved in the regulation of sleep-wake cycles, and is thought to play a role in the development of insomnia. It is also involved in the regulation of neurogenesis, the process by which new neurons are generated in the brain.

HTR1E is a potential drug target for the treatment of chronic pain, anxiety, and insomnia. Currently, there are no approved drugs that specifically target HTR1E. However, there is research being conducted to develop small molecule compounds that can specifically modulate HTR1E activity. These compounds are thought to work by binding to HTR1E and modulating its activity, which could lead to the therapeutic treatment of chronic pain, anxiety, and insomnia.

In conclusion, HTR1E is a G protein-coupled receptor that is involved in the regulation of various physiological processes, including pain, anxiety, and sleep-wake cycles. It is a potent receptor for the neurotransmitter serotonin, and is thought to play a key role in the development of chronic pain. Currently, there is research being conducted to develop small molecule compounds that can specifically modulate HTR1E activity and may lead to the therapeutic treatment of chronic pain, anxiety, and insomnia.

Protein Name: 5-hydroxytryptamine Receptor 1E

Functions: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity

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