HTRA4: A Potential Drug Target Or Biomarker for Various Diseases

Target Name: HTRA4

NCBI ID: G203100

HTRA4: A Potential Drug Target Or Biomarker for Various Diseases

High-temperature requirement factor A4 (HTRA4) is a protein that is expressed in various cell types of the human body. It is a key regulator of the thermal stability of proteins and plays a crucial role in the maintenance of cellular homeostasis. The HTRA4 gene has been identified as a potential drug target or biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. In this article, we will explore the biology and potential therapeutic applications of HTRA4.

Biochemistry

HTRA4 is a member of the heat shock protein (HSP) family, which includes a variety of proteins that are expressed in response to increased levels of thermal stress, such as thermal shock, osmotic stress, and exposure to radiation. HSPs are involved in the regulation of protein stability and dynamics, and play a key role in maintaining cellular homeostasis in a variety of cellular environments.

HTRA4 is a 21-kDa protein that is expressed in various cell types, including muscle, nerve, heart, and liver cells. It is highly conserved, with a calculated pI of 6.5 and a predicted localization in the cytoplasm. HTRA4 is associated with the endoplasmic reticulum (ER) and can be expressed and purified from various cell types, making it a promising protein for drug development.

Function

HTRA4 is involved in the regulation of protein stability and dynamics, and plays a key role in the maintenance of cellular homeostasis. It is a critical regulator of the thermal stability of various proteins, including cytoskeletal proteins, enzymes, and nucleic acids.

HTRA4 is involved in the regulation of protein stability by affecting the stability of its own subunit, which consists of a catalytic alpha-helices and a regulatory beta-sheet. The alpha-helices are involved in the regulation of protein stability by various means, including the formation of inclusion complexes with other proteins, which can increase the stability of the protein. The regulatory beta-sheet is involved in the regulation of protein stability by affecting the formation of hydrogen bonds between the beta-sheet and other proteins or nucleic acids.

HTRA4 is also involved in the regulation of protein dynamics by affecting the dynamics of its own subunit. The alpha-helices are involved in the regulation of protein dynamics by affecting the dynamics of the subunit, while the regulatory beta-sheet is involved in the regulation of protein dynamics by affecting the dynamics of the entire protein.

Potential Therapeutic Applications

HTRA4 has been identified as a potential drug target or biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

In cancer, HTRA4 has been shown to be involved in the regulation of cellular signaling pathways, including the regulation of cell proliferation, apoptosis, and angiogenesis. HTRA4 has been shown to play a key role in the regulation of the thermal stability of various proteins that are involved in cell signaling pathways, including the regulation of cell growth, apoptosis, and angiogenesis.

In neurodegenerative diseases, HTRA4 has been shown to be involved in the regulation of cellular signaling pathways and the maintenance of cellular homeostasis. HTRA4 has been shown to play a key role in the regulation of the thermal stability of various proteins that are involved in cellular signaling pathways, including the regulation of neurotransmitter release, synaptic plasticity, and neuroprotection.

In autoimmune disorders, HTRA4 has been shown to be involved in the regulation of cellular signaling pathways and the maintenance of cellular homeostasis. HTRA4 has been shown to play

Protein Name: HtrA Serine Peptidase 4

Functions: Serine protease

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